N-(2-chloro-3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)phenyl)propane-1-sulfonamide

Base Information

Chemical Name:N-(2-chloro-3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)phenyl)propane-1-sulfonamide
CAS No.:1307272-64-5
Molecular Formula:C₂₀H₂₂Cl₂N₄O₃S₂
Molecular Weight:501.458
Hs Code.:

Synonyms:N-(2-chloro-3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)phenyl)propane-1-sulfonamide

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Chemical Property of N-(2-chloro-3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)phenyl)propane-1-sulfonamide

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Technology Process of N-(2-chloro-3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)phenyl)propane-1-sulfonamide

There total 6 articles about N-(2-chloro-3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)phenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.4%

: 1195769-50-6
3-hydroxy-2,2-dimethylpropanethioamide

: 1307272-07-6
N-(3-(2-bromo-2-(2-chloropyrimidin-4-yl)acetyl)-2-chlorophenyl)propane-1-sulfonamide

: 1307272-64-5
N-(2-chloro-3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)phenyl)propane-1-sulfonamide

Guidance literature:: In ISOPROPYLAMIDE; at 25 - 85 ℃; for 3h; Inert atmosphere;

Reference yield:

: 120100-15-4
methyl 3-amino-2-chlorobenzoate

: 1307272-64-5
N-(2-chloro-3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / 6.5 h / 0 - 30 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - -10 °C / Inert atmosphere

2.2: -10 - 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1 h / 25 °C / Inert atmosphere

4.1: ISOPROPYLAMIDE / 3 h / 25 - 85 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; lithium hexamethyldisilazane; In tetrahydrofuran; ISOPROPYLAMIDE;

Reference yield:

: 53553-14-3
2-chloro-3-nitrobenzoic acid methyl ester

: 1307272-64-5
N-(2-chloro-3-(5-(2-chloropyrimidin-4-yl)-2-(1-hydroxy-2-methylpropan-2-yl)thiazol-4-yl)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / methanol / 3.5 h / 25 °C / 2585.81 Torr / Inert atmosphere

2.1: pyridine / 6.5 h / 0 - 30 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 3 h / -30 - -10 °C / Inert atmosphere

3.2: -10 - 20 °C / Inert atmosphere

4.1: N-Bromosuccinimide / ISOPROPYLAMIDE / 1 h / 25 °C / Inert atmosphere

5.1: ISOPROPYLAMIDE / 3 h / 25 - 85 °C / Inert atmosphere

With pyridine; N-Bromosuccinimide; hydrogen; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; ISOPROPYLAMIDE;