N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylaminocarbonylamino)-5-fluorophenylcarboxamide

Base Information

Chemical Name:N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylaminocarbonylamino)-5-fluorophenylcarboxamide
CAS No.:330941-33-8
Molecular Formula:C₂₅H₁₉BrFN₅O₄S
Molecular Weight:584.425
Hs Code.:

Synonyms:N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylaminocarbonylamino)-5-fluorophenylcarboxamide

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Chemical Property of N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylaminocarbonylamino)-5-fluorophenylcarboxamide

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Technology Process of N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylaminocarbonylamino)-5-fluorophenylcarboxamide

There total 4 articles about N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylaminocarbonylamino)-5-fluorophenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 330943-02-7
N-(5-bromo-2-pyridinyl)(2-nitro)-5-fluorophenylcarboxamide

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 330941-33-8
N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylaminocarbonylamino)-5-fluorophenylcarboxamide

Guidance literature:: 4-(2'-tert-butylaminosulfonylphenyl)aniline; With 4-methyl-morpholine; di(succinimido) carbonate; In acetonitrile; at 20 ℃; for 0.5h;

N-(5-bromo-2-pyridinyl)(2-nitro)-5-fluorophenylcarboxamide; In acetonitrile; at 20 ℃; for 3h;

With trifluoroacetic acid; at 20 ℃;

Reference yield: 18.0%

: 330943-03-8
N-(5-bromo-2-pyridinyl)-(2-amino)-5-fluorophenylcarboxamide

: 74124-79-1
di(succinimido) carbonate

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 330941-33-8
N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylaminocarbonylamino)-5-fluorophenylcarboxamide

Guidance literature:: With 4-methyl-morpholine; trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 320-98-9
5-fluoro-2-nitrobenzoic acid

: 330941-33-8
N-(5-bromo-2-pyridinyl)-(2-4-[(2-aminosulfonyl)phenyl]phenylaminocarbonylamino)-5-fluorophenylcarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine; trichlorophosphate / 0.5 h

2.1: di(succinimido) carbonate; 4-methyl-morpholine / acetonitrile / 0.5 h / 20 °C

2.2: 3 h / 20 °C

2.3: 20 °C

With 4-methyl-morpholine; pyridine; di(succinimido) carbonate; trichlorophosphate; In acetonitrile;