N-allyl-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

Base Information

• Chemical Name: N-allyl-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide
• CAS No.: 459457-03-5
• Molecular Formula: C₁₇H₂₅NO₄S
• Molecular Weight: 339.456
• Mol file: 459457-03-5.mol

Synonyms:N-allyl-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

Chemical Property of N-allyl-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-allyl-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

There total 5 articles about N-allyl-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

allyl bromide (106-95-6) + 4-Methyl-N-((4R,5R)-2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide (459457-02-4) → N-allyl-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide (459457-03-5)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)00833-X

Reference yield:

(2S,3S)-3-hydroxy-2-(4-methylphenylsulfonamido)butanoic acid (34235-88-6) → N-allyl-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide (459457-03-5)

Guidance literature:

Multi-step reaction with 4 steps

1: KHCO₃ / dimethylformamide

2: LiBH₄ / tetrahydrofuran

3: TsOH / CH₂Cl₂

4: 96 percent / NaH / dimethylformamide

With lithium borohydride; sodium hydride; potassium hydrogencarbonate; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)00833-X

Reference yield:

(2S,3R)-methyl-N-(4-methylphenylsulfonyl)-3-hydroxy-2-aminobutanoate (43188-53-0) → N-allyl-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide (459457-03-5)

Guidance literature:

Multi-step reaction with 3 steps

1: LiBH₄ / tetrahydrofuran

2: TsOH / CH₂Cl₂

3: 96 percent / NaH / dimethylformamide

With lithium borohydride; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(02)00833-X

upstream raw materials:

allyl bromide

4-Methyl-N-((4R,5R)-2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide

(2S,3S)-3-hydroxy-2-(4-methylphenylsulfonamido)butanoic acid

(2S,3R)-methyl-N-(4-methylphenylsulfonyl)-3-hydroxy-2-aminobutanoate

Downstream raw materials:

N-[1-(tert-butyl-diphenyl-silanyloxymethyl)-2-hydroxy-propyl]-N-(2-iodo-ethyl)-4-methyl-benzenesulfonamide

N-(2-hydroxy-1-trityloxymethyl-propyl)-N-(2-iodo-ethyl)-4-methyl-benzenesulfonamide

N-[1-(tert-butyl-diphenyl-silanyloxymethyl)-2-oxo-propyl]-N-(2-iodo-ethyl)-4-methyl-benzenesulfonamide

N-(2-iodo-ethyl)-4-methyl-N-(2,2,4-trimethyl-[1,3]dioxan-5-yl)-benzenesulfonamide