(7aS)-p-hydroxyphenopyrrozin

Base Information

Chemical Name:(7aS)-p-hydroxyphenopyrrozin
CAS No.:887602-12-2
Molecular Formula:C₁₃H₁₃NO₃
Molecular Weight:231.251
Hs Code.:

Synonyms:(7aS)-p-hydroxyphenopyrrozin

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Chemical Property of (7aS)-p-hydroxyphenopyrrozin

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Technology Process of (7aS)-p-hydroxyphenopyrrozin

There total 7 articles about (7aS)-p-hydroxyphenopyrrozin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1367352-96-2
C₁₉H₂₇NO₃Si

: 887602-12-2
(7aS)-p-hydroxyphenopyrrozin

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at -40 ℃; for 0.5h;
DOI:10.1016/j.tetlet.2012.01.098

Reference yield:

: 109180-95-2,108310-01-6
(S)-tert-butyl 2-(3-ethoxy-3-oxopropanoyl)pyrrolidine-1-carboxylate

: 887602-12-2
(7aS)-p-hydroxyphenopyrrozin

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / tetrahydrofuran / 4 h / -65 - -40 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water / 0.67 h / 0 - 60 °C

3: platinum(IV) oxide; hydrogen / methanol; ethyl acetate / 6 h / 20 °C

4: water; trifluoroacetic acid / dichloromethane / 2 h

5: ammonia / water / 0.67 h / 75 °C / sealed tube

6: pyridine; silver nitrate / tetrahydrofuran / 5 h / 20 °C

7: N,N,N,N,N,N-hexamethylphosphoric triamide; oxygen; lithium diisopropyl amide; phosphorous acid trimethyl ester / tetrahydrofuran / 4 h / -75 - -65 °C

8: sodium periodate; ruthenium trichloride / tetrachloromethane; water; acetonitrile / 2 h / -10 - -5 °C

9: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / -40 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; platinum(IV) oxide; ruthenium trichloride; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; ammonia; water; hydrogen; oxygen; sodium carbonate; silver nitrate; triethylamine; trifluoroacetic acid; lithium diisopropyl amide; phosphorous acid trimethyl ester; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; water; ethyl acetate; acetonitrile; 2: Suzuki coupling;
DOI:10.1016/j.tetlet.2012.01.098

Reference yield:

: 1367352-86-0
C₂₀H₂₉NO₅

: 887602-12-2
(7aS)-p-hydroxyphenopyrrozin

Guidance literature:: Multi-step reaction with 6 steps

1: water; trifluoroacetic acid / dichloromethane / 2 h

2: ammonia / water / 0.67 h / 75 °C / sealed tube

3: pyridine; silver nitrate / tetrahydrofuran / 5 h / 20 °C

4: N,N,N,N,N,N-hexamethylphosphoric triamide; oxygen; lithium diisopropyl amide; phosphorous acid trimethyl ester / tetrahydrofuran / 4 h / -75 - -65 °C

5: sodium periodate; ruthenium trichloride / tetrachloromethane; water; acetonitrile / 2 h / -10 - -5 °C

6: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / -40 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; ruthenium trichloride; sodium periodate; tetrabutyl ammonium fluoride; ammonia; water; oxygen; silver nitrate; trifluoroacetic acid; lithium diisopropyl amide; phosphorous acid trimethyl ester; In tetrahydrofuran; tetrachloromethane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tetlet.2012.01.098