(4S,5R)-methyl 4,5-dimethyl-5-(4-methylphenyl)-2-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate

Base Information

Chemical Name:(4S,5R)-methyl 4,5-dimethyl-5-(4-methylphenyl)-2-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate
CAS No.:1309465-33-5
Molecular Formula:C₂₀H₂₂N₂O₂
Molecular Weight:322.407
Hs Code.:

Synonyms:(4S,5R)-methyl 4,5-dimethyl-5-(4-methylphenyl)-2-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate

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Chemical Property of (4S,5R)-methyl 4,5-dimethyl-5-(4-methylphenyl)-2-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate

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Technology Process of (4S,5R)-methyl 4,5-dimethyl-5-(4-methylphenyl)-2-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate

There total 3 articles about (4S,5R)-methyl 4,5-dimethyl-5-(4-methylphenyl)-2-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1309465-32-4
(4S,5R)-methyl 4,5-dimethyl-5-(4-methylphenyl)-2-thioxoimidazolidine-4-carboxylate

: 98-80-6
phenylboronic acid

: 1309465-33-5
(4S,5R)-methyl 4,5-dimethyl-5-(4-methylphenyl)-2-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; In N,N-dimethyl-formamide; at 130 ℃; for 1h; Microwave irradiation; Inert atmosphere;
DOI:10.1002/anie.201101034

Reference yield:

: 26349-74-6,26349-75-7,58526-55-9,21055-39-0
2-isothiocyanatopropionic acid methyl ester

: 1309465-33-5
(4S,5R)-methyl 4,5-dimethyl-5-(4-methylphenyl)-2-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: strontium diisopropoxide; C₃₈H₃₂N₂O₆ / tetrahydrofuran; chloroform / 20 h / 20 °C / Molecular sieve; Inert atmosphere

2: Schwartz's reagent / toluene / 4 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate / N,N-dimethyl-formamide / 1 h / 130 °C / Microwave irradiation; Inert atmosphere

With strontium diisopropoxide; Schwartz's reagent; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; C₃₈H₃₂N₂O₆; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene; 1: Mannich type reaction;
DOI:10.1002/anie.201101034

Reference yield:

: 540485-26-5
P,P-diphenyl-N-[1-(4-methylphenyl)ethylidene]phosphinic amide

: 1309465-33-5
(4S,5R)-methyl 4,5-dimethyl-5-(4-methylphenyl)-2-phenyl-4,5-dihydro-1H-imidazole-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: strontium diisopropoxide; C₃₈H₃₂N₂O₆ / tetrahydrofuran; chloroform / 20 h / 20 °C / Molecular sieve; Inert atmosphere

2: Schwartz's reagent / toluene / 4 h / 20 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate / N,N-dimethyl-formamide / 1 h / 130 °C / Microwave irradiation; Inert atmosphere

With strontium diisopropoxide; Schwartz's reagent; tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) thiophene-2-carboxylate; C₃₈H₃₂N₂O₆; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide; toluene; 1: Mannich type reaction;
DOI:10.1002/anie.201101034