(E)-5-{(2,2-Bis-phenylsulfanyl-vinyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester

Base Information

• Chemical Name: (E)-5-{(2,2-Bis-phenylsulfanyl-vinyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester
• CAS No.: 221100-33-0
• Molecular Formula: C₃₁H₃₂INO₅S₂
• Molecular Weight: 689.635

Synonyms:(E)-5-{(2,2-Bis-phenylsulfanyl-vinyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester

Chemical Property of (E)-5-{(2,2-Bis-phenylsulfanyl-vinyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester

Chemical Property:

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Technology Process of (E)-5-{(2,2-Bis-phenylsulfanyl-vinyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester

There total 4 articles about (E)-5-{(2,2-Bis-phenylsulfanyl-vinyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(2-iodo-4,5-dimethoxyphenyl)acetyl chloride (35334-76-0) + (E)-5-(2,2-Bis-phenylsulfanyl-vinylamino)-pent-2-enoic acid ethyl ester (221100-32-9) → (E)-5-{(2,2-Bis-phenylsulfanyl-vinyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester (221100-33-0)

Guidance literature:

With N,N-diethylaniline; In benzene; Heating;

DOI:10.1016/S0040-4039(98)02550-7

Reference yield:

Bis(phenylsulfanyl)acetaldehyde (153823-24-6) → (E)-5-{(2,2-Bis-phenylsulfanyl-vinyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester (221100-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / MgSO₄ / diethyl ether

2: 88 percent / PhNEt₂ / benzene / Heating

With magnesium sulfate; N,N-diethylaniline; In diethyl ether; benzene;

DOI:10.1016/S0040-4039(98)02550-7

Reference yield:

(E)-5-Amino-pent-2-enoic acid ethyl ester (221100-31-8) → (E)-5-{(2,2-Bis-phenylsulfanyl-vinyl)-[2-(2-iodo-4,5-dimethoxy-phenyl)-acetyl]-amino}-pent-2-enoic acid ethyl ester (221100-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / MgSO₄ / diethyl ether

2: 88 percent / PhNEt₂ / benzene / Heating

With magnesium sulfate; N,N-diethylaniline; In diethyl ether; benzene;

DOI:10.1016/S0040-4039(98)02550-7

upstream raw materials:

(2-iodo-4,5-dimethoxyphenyl)acetyl chloride

(E)-5-(2,2-Bis-phenylsulfanyl-vinylamino)-pent-2-enoic acid ethyl ester

Bis(phenylsulfanyl)acetaldehyde

(E)-5-Amino-pent-2-enoic acid ethyl ester

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