6-Bromo-1-(tert-butyl-diphenyl-silanyl)-3-methyl-4-propyl-1H-pyridin-2-one

Base Information

• Chemical Name: 6-Bromo-1-(tert-butyl-diphenyl-silanyl)-3-methyl-4-propyl-1H-pyridin-2-one
• CAS No.: 192189-63-2
• Molecular Formula: C₂₅H₃₀BrNOSi
• Molecular Weight: 468.509
• Mol file: 192189-63-2.mol

Synonyms:6-Bromo-1-(tert-butyl-diphenyl-silanyl)-3-methyl-4-propyl-1H-pyridin-2-one

Chemical Property of 6-Bromo-1-(tert-butyl-diphenyl-silanyl)-3-methyl-4-propyl-1H-pyridin-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Bromo-1-(tert-butyl-diphenyl-silanyl)-3-methyl-4-propyl-1H-pyridin-2-one

There total 5 articles about 6-Bromo-1-(tert-butyl-diphenyl-silanyl)-3-methyl-4-propyl-1H-pyridin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butylchlorodiphenylsilane (58479-61-1) + 6-Bromo-3-methyl-4-propyl-1H-pyridin-2-one (192189-62-1) → 6-Bromo-1-(tert-butyl-diphenyl-silanyl)-3-methyl-4-propyl-1H-pyridin-2-one (192189-63-2)

Guidance literature:

With triethylamine; In dichloromethane; for 24h; Ambient temperature;

DOI:10.1016/S0040-4020(97)90398-7

Reference yield:

methyl 2-methyl-3-oxohexanoate (120040-67-7) → 6-Bromo-1-(tert-butyl-diphenyl-silanyl)-3-methyl-4-propyl-1H-pyridin-2-one (192189-63-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 44 percent / AcONH₄, AcOH / benzene / 48 h / Heating

2: 9.00 g / KOH / ethanol / 5 h / Ambient temperature

3: 1.) PCl₅, 2.) HBr / 1.) CH₂Cl₂, rt, 12 h, 2.) CH₂Cl₂, -78 deg C -> rt

4: 100 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

With potassium hydroxide; phosphorus pentachloride; ammonium acetate; hydrogen bromide; acetic acid; triethylamine; In ethanol; dichloromethane; benzene;

DOI:10.1016/S0040-4020(97)90398-7

Reference yield:

methyl 3-oxohexanoate (30414-54-1) → 6-Bromo-1-(tert-butyl-diphenyl-silanyl)-3-methyl-4-propyl-1H-pyridin-2-one (192189-63-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 86 percent / NaH / 1,2-dimethoxy-ethane / 3 h / Ambient temperature

2: 44 percent / AcONH₄, AcOH / benzene / 48 h / Heating

3: 9.00 g / KOH / ethanol / 5 h / Ambient temperature

4: 1.) PCl₅, 2.) HBr / 1.) CH₂Cl₂, rt, 12 h, 2.) CH₂Cl₂, -78 deg C -> rt

5: 100 percent / Et₃N / CH₂Cl₂ / 24 h / Ambient temperature

With potassium hydroxide; phosphorus pentachloride; ammonium acetate; hydrogen bromide; sodium hydride; acetic acid; triethylamine; In 1,2-dimethoxyethane; ethanol; dichloromethane; benzene;

DOI:10.1016/S0040-4020(97)90398-7

upstream raw materials:

tert-butylchlorodiphenylsilane

6-Bromo-3-methyl-4-propyl-1H-pyridin-2-one

methyl 2-methyl-3-oxohexanoate

methyl 3-oxohexanoate

Downstream raw materials:

6-Bromo-1-(tert-butyl-diphenyl-silanyl)-4-((S)-1-hydroxy-propyl)-3-methyl-1H-pyridin-2-one