Technology Process of 2-((E)-6-bromo-3,4-dimethyl-4-hexenyl)-2-cyclohexenone
There total 16 articles about 2-((E)-6-bromo-3,4-dimethyl-4-hexenyl)-2-cyclohexenone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
phosphorus tribromide;
In
hexane;
for 0.166667h;
DOI:10.1021/jo980188t
- Guidance literature:
-
Multi-step reaction with 11 steps
1: LDA
2: 1.) NaH / 1.) Et2O, 0 deg, 20 min, 2.) 4 h
3: 94 percent / Pd(0) / 1,2-dichloro-ethane; hexane / 72 h / Ambient temperature
4: DIBALH
5: imidazole
6: Li, liquid NH3
7: I2, PPh3, imidazole
8: 1.) t-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) HMPA, THF, 2 h
9: 85 percent / conc. HCl / ethanol / 7 h / Ambient temperature
10: Et3N / CH2Cl2 / 3 h / 0 °C
11: LiBr / acetone / 1 h / Heating
With
1H-imidazole; hydrogenchloride; ammonia; iodine; tert.-butyl lithium; lithium; sodium hydride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; lithium bromide; lithium diisopropyl amide;
palladium;
In
ethanol; hexane; dichloromethane; 1,2-dichloro-ethane; acetone;
DOI:10.1021/jo980188t
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 1.) NaH / 1.) Et2O, 0 deg, 20 min, 2.) 4 h
2: 94 percent / Pd(0) / 1,2-dichloro-ethane; hexane / 72 h / Ambient temperature
3: DIBALH
4: imidazole
5: Li, liquid NH3
6: I2, PPh3, imidazole
7: 1.) t-BuLi / 1.) THF, hexane, -78 deg C, 1 h, 2.) HMPA, THF, 2 h
8: 85 percent / conc. HCl / ethanol / 7 h / Ambient temperature
9: Et3N / CH2Cl2 / 3 h / 0 °C
10: LiBr / acetone / 1 h / Heating
With
1H-imidazole; hydrogenchloride; ammonia; iodine; tert.-butyl lithium; lithium; sodium hydride; diisobutylaluminium hydride; triethylamine; triphenylphosphine; lithium bromide;
palladium;
In
ethanol; hexane; dichloromethane; 1,2-dichloro-ethane; acetone;
DOI:10.1021/jo980188t
