1-(3,3-Diphenyl-propyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester

Base Information

• Chemical Name: 1-(3,3-Diphenyl-propyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester
• CAS No.: 10461-95-7
• Molecular Formula: C₂₉H₃₃NO₂
• Molecular Weight: 427.587

Synonyms:1-(3,3-Diphenyl-propyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester

Chemical Property of 1-(3,3-Diphenyl-propyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

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Technology Process of 1-(3,3-Diphenyl-propyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester

There total 3 articles about 1-(3,3-Diphenyl-propyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Normeperidine (77-17-8) + 1-bromo-3,3-diphenylpropane (20017-68-9) → 1-(3,3-Diphenyl-propyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester (10461-95-7)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 140 ℃; for 1.33333h; Inert atmosphere; Microwave irradiation;

DOI:10.1016/j.bmcl.2012.09.080

Reference yield:

4-phenyl-piperidine-4-carboxylic acid (3627-45-0) → 1-(3,3-Diphenyl-propyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester (10461-95-7)

Guidance literature:

Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 20 °C

2: N-ethyl-N,N-diisopropylamine / 1.33 h / 140 °C / Inert atmosphere; Microwave irradiation

With N-ethyl-N,N-diisopropylamine; In acetonitrile;

DOI:10.1016/j.bmcl.2012.09.080

Reference yield:

→ 1-(3,3-Diphenyl-propyl)-4-phenyl-piperidine-4-carboxylic acid ethyl ester (10461-95-7)

Guidance literature:

Aldehyd (III), 4-Phenyl-4-carbethoxypyridin, H2 (Pd-C);

upstream raw materials:

4-phenyl-piperidine-4-carboxylic acid

Normeperidine

1-bromo-3,3-diphenylpropane

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