Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-OMe

Base Information

Chemical Name:Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-OMe
CAS No.:73995-34-3
Molecular Formula:C₅₂H₈₀ClN₉O₁₅
Molecular Weight:1106.71
Hs Code.:

Boc-Leu-Glu(OBu<sup>t</sup>)-Gly-Pro-Pro-Gln-Lys<Z(2-Cl)>-OMe

Synonyms:Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-OMe

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-OMe

Chemical Property:

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Technology Process of Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-OMe

There total 14 articles about Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4666-16-4
5-tert-butyl 1-(2,5-dioxopyrrolidin-1-yl) (S)-2-{[(phenylmethoxy)carbonyl]amino}glutarate

: 73995-34-3
Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-OMe

Guidance literature:: Multi-step reaction with 4 steps

1: 82.2 percent / 1.) TEA / tetrahydrofuran / 96 h / Ambient temperature

2: H₂ / 5percent palladium-charcoal / methanol / 2.5 h / 35 °C

3: 1.) TEA / CHCl₃ / 72 h / Ambient temperature

4: 1.) N-methylmorpholine, DCC, 2.) 1-hydroxybenzotriazole (HOBt), DCC / tetrahydrofuran / 96 h / 0 - 20 °C

With 4-methyl-morpholine; TEA; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; chloroform;
DOI:10.1246/bcsj.53.192

Reference yield:

: 73995-32-1
(S)-2-((S)-4-Carbamoyl-2-{[(S)-1-((S)-pyrrolidine-2-carbonyl)-pyrrolidine-2-carbonyl]-amino}-butyrylamino)-6-(2-chloro-benzyloxycarbonylamino)-hexanoic acid methyl ester

: 73995-24-1
Boc-Leu-Glu(OBu^t)-Gly-OH

: 73995-34-3
Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-OMe

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 - 20 ℃; for 96h; Yield given;
DOI:10.1246/bcsj.53.192

Reference yield:

: 3392-09-4
Boc-Leu-ONSu

: 73995-34-3
Boc-Leu-Glu(OBu^t)-Gly-Pro-Pro-Gln-Lys-OMe

Guidance literature:: Multi-step reaction with 3 steps

1: dimethylformamide; CH₂Cl₂ / 1 h / Ambient temperature

2: 1 M NaOH / dioxane / 2 h / Ambient temperature

3: 1.) N-methylmorpholine, DCC, 2.) 1-hydroxybenzotriazole (HOBt), DCC / tetrahydrofuran / 96 h / 0 - 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.53.192