[N-methyl-N-2-[(tert-butoxycarbonylmethylamino)acetoxymethyl]-4,5-difluoro-phenyl]carbamic acid 1-chloroethyl ester

Base Information

Chemical Name:[N-methyl-N-2-[(tert-butoxycarbonylmethylamino)acetoxymethyl]-4,5-difluoro-phenyl]carbamic acid 1-chloroethyl ester
CAS No.:338990-34-4
Molecular Formula:C₁₉H₂₅ClF₂N₂O₆
Molecular Weight:450.867
Hs Code.:

Synonyms:[N-methyl-N-2-[(tert-butoxycarbonylmethylamino)acetoxymethyl]-4,5-difluoro-phenyl]carbamic acid 1-chloroethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [N-methyl-N-2-[(tert-butoxycarbonylmethylamino)acetoxymethyl]-4,5-difluoro-phenyl]carbamic acid 1-chloroethyl ester

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Technology Process of [N-methyl-N-2-[(tert-butoxycarbonylmethylamino)acetoxymethyl]-4,5-difluoro-phenyl]carbamic acid 1-chloroethyl ester

There total 3 articles about [N-methyl-N-2-[(tert-butoxycarbonylmethylamino)acetoxymethyl]-4,5-difluoro-phenyl]carbamic acid 1-chloroethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13734-36-6
N-(tert-butoxycarbonyl)sarcosine

: (4,5-difluoro-2-hydroxymethyl-phenyl)-methyl-carbamic acid 1-chloro-ethyl ester

: 338990-34-4
[N-methyl-N-2-[(tert-butoxycarbonylmethylamino)acetoxymethyl]-4,5-difluoro-phenyl]carbamic acid 1-chloroethyl ester

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 ℃;
DOI:10.1016/S0960-894X(02)00892-2

Reference yield:

: (4,5-difluoro-2-methylaminophenyl)methanol

: 338990-34-4
[N-methyl-N-2-[(tert-butoxycarbonylmethylamino)acetoxymethyl]-4,5-difluoro-phenyl]carbamic acid 1-chloroethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: diisopropylamine / CH₂Cl₂ / 0 °C

2: WSCI; DMAP / CH₂Cl₂ / 0 °C

With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; diisopropylamine; In dichloromethane;
DOI:10.1016/S0960-894X(02)00892-2