N₂-(4'-cyanophenyl)-6-[4''-(2-cyclopropylethynyl)-2'',6''-dimethylphenoxy]pyridin-2,3-diamine

Base Information

• Chemical Name: N₂-(4'-cyanophenyl)-6-[4''-(2-cyclopropylethynyl)-2'',6''-dimethylphenoxy]pyridin-2,3-diamine
• CAS No.: 1221441-33-3
• Molecular Formula: C₂₅H₂₂N₄O
• Molecular Weight: 394.476

Synonyms:N₂-(4'-cyanophenyl)-6-[4''-(2-cyclopropylethynyl)-2'',6''-dimethylphenoxy]pyridin-2,3-diamine

Chemical Property of N₂-(4'-cyanophenyl)-6-[4''-(2-cyclopropylethynyl)-2'',6''-dimethylphenoxy]pyridin-2,3-diamine

Chemical Property:

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Technology Process of N₂-(4'-cyanophenyl)-6-[4''-(2-cyclopropylethynyl)-2'',6''-dimethylphenoxy]pyridin-2,3-diamine

There total 2 articles about N₂-(4'-cyanophenyl)-6-[4''-(2-cyclopropylethynyl)-2'',6''-dimethylphenoxy]pyridin-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

N-(4'-cyanophenyl)-6-[4''-(2-cyclopropylethynyl)-2'',6''-dimethyl]phenoxy-3-nitro-pyridin-2-amine (1221441-32-2) → N2-(4'-cyanophenyl)-6-[4''-(2-cyclopropylethynyl)-2'',6''-dimethylphenoxy]pyridin-2,3-diamine (1221441-33-3)

Guidance literature:

With sodium dithionite; ammonium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h;

DOI:10.1021/jm100738d

Reference yield:

Cyclopropylacetylene (6746-94-7) + N2-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-iodo)phenoxy-3-nitropyridin-2-amine (1191279-71-6) → N2-(4'-cyanophenyl)-6-[4''-(2-cyclopropylethynyl)-2'',6''-dimethylphenoxy]pyridin-2,3-diamine (1221441-33-3)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide / C₄₁H₃₅ClP₂Pd / N,N-dimethyl-formamide / 7 h / 20 °C / Inert atmosphere

2: sodium dithionite; ammonia / water; tetrahydrofuran / 2 h / 20 °C

With copper(l) iodide; sodium dithionite; ammonia; triethylamine; C₄₁H₃₅ClP₂Pd; In tetrahydrofuran; water; N,N-dimethyl-formamide;

upstream raw materials:

N-(4'-cyanophenyl)-6-[4''-(2-cyclopropylethynyl)-2'',6''-dimethyl]phenoxy-3-nitro-pyridin-2-amine

Cyclopropylacetylene

N₂-(4'-cyanophenyl)-6-(2'',6''-dimethyl-4''-iodo)phenoxy-3-nitropyridin-2-amine

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