20-acetyl-2'-O-(tert-butyldimethylsilyl)-4-deacetyl-5,6-dehydro-7-oxo-5-O-secopaclitaxel

Base Information

• Chemical Name: 20-acetyl-2'-O-(tert-butyldimethylsilyl)-4-deacetyl-5,6-dehydro-7-oxo-5-O-secopaclitaxel
• CAS No.: 344549-99-1
• Molecular Formula: C₅₃H₆₃NO₁₄Si
• Molecular Weight: 966.167

Synonyms:20-acetyl-2'-O-(tert-butyldimethylsilyl)-4-deacetyl-5,6-dehydro-7-oxo-5-O-secopaclitaxel

Chemical Property of 20-acetyl-2'-O-(tert-butyldimethylsilyl)-4-deacetyl-5,6-dehydro-7-oxo-5-O-secopaclitaxel

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 20-acetyl-2'-O-(tert-butyldimethylsilyl)-4-deacetyl-5,6-dehydro-7-oxo-5-O-secopaclitaxel

There total 1 articles about 20-acetyl-2'-O-(tert-butyldimethylsilyl)-4-deacetyl-5,6-dehydro-7-oxo-5-O-secopaclitaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2'-O-(tert-butyldimethylsilyl)paclitaxel (114655-02-6) → 20-acetyl-2'-O-(tert-butyldimethylsilyl)-4-deacetyl-5,6-dehydro-7-oxo-5-O-secopaclitaxel (344549-99-1)

Guidance literature:

With jones reagent; In acetone; at 20 ℃; for 0.5h;

DOI:10.1021/jo0015467

Reference yield: 80.0%

20-acetyl-2'-O-(tert-butyldimethylsilyl)-4-deacetyl-5,6-dehydro-7-oxo-5-O-secopaclitaxel (344549-99-1) → C47H50NO14C6H13Si (344550-00-1)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jo0015467

Reference yield: 38.0%

acetic anhydride (108-24-7) + 20-acetyl-2'-O-(tert-butyldimethylsilyl)-4-deacetyl-5,6-dehydro-7-oxo-5-O-secopaclitaxel (344549-99-1) → Benzoic acid (1S,2S,3R,4S,8S,10R,13S)-2,10-diacetoxy-4-acetoxymethyl-13-[(2R,3S)-3-benzoylamino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionyloxy]-4-hydroxy-8,12,15,15-tetramethyl-7,9-dioxo-tricyclo[9.3.1.03,8]pentadeca-5,11-dien-1-yl ester + Benzoic acid (1S,2S,3R,4S,8S,10R,13S)-4,10-diacetoxy-4-acetoxymethyl-13-[(2R,3S)-3-benzoylamino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionyloxy]-1-hydroxy-8,12,15,15-tetramethyl-7,9-dioxo-tricyclo[9.3.1.03,8]pentadeca-5,11-dien-2-yl ester (344550-02-3) + benzoic acid 4,9,10-triacetoxy-4-acetoxymethyl-13-[3-benzoylamino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionyloxy]-1-hydroxy-8,12,15,15-tetramethyl-7-oxo-tricyclo[9.3.1.03,8]pentadeca-5,9,11-trien-2-yl ester

Guidance literature:

With dmap; In toluene; at 80 ℃; for 17h;

DOI:10.1021/jo0015467

upstream raw materials:

2'-O-(tert-butyldimethylsilyl)paclitaxel

Downstream raw materials:

Benzoic acid (1S,2S,3R,4S,8S,10R,13S)-4,10-diacetoxy-4-acetoxymethyl-13-[(2R,3S)-3-benzoylamino-2-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionyloxy]-1-hydroxy-8,12,15,15-tetramethyl-7,9-dioxo-tricyclo[9.3.1.0^3,8]pentadeca-5,11-dien-2-yl ester

C₄₇H₅₀NO₁₄C₆H₁₃Si

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 344549-99-1 20-acetyl-2'-O-(tert-butyldimethylsilyl)-4-deacetyl-5,6-dehydro-7-oxo-5-O-secopaclitaxel

Send

Send

Metric Ton KG G Pound L ML

Send

Send