Carbonic acid 4-(tert-butoxycarbonylamino-methyl)-5-{(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-2-methyl-pyridin-3-yl ester tert-butyl ester

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Chemical Name:Carbonic acid 4-(tert-butoxycarbonylamino-methyl)-5-{(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-2-methyl-pyridin-3-yl ester tert-butyl ester
CAS No.:176754-78-2
Molecular Formula:C₄₅H₅₄N₄O₉
Molecular Weight:794.945
Hs Code.:

Carbonic acid 4-(tert-butoxycarbonylamino-methyl)-5-{(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-2-methyl-pyridin-3-yl ester tert-butyl ester

Synonyms:Carbonic acid 4-(tert-butoxycarbonylamino-methyl)-5-{(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-2-methyl-pyridin-3-yl ester tert-butyl ester

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Chemical Property of Carbonic acid 4-(tert-butoxycarbonylamino-methyl)-5-{(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-2-methyl-pyridin-3-yl ester tert-butyl ester

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Technology Process of Carbonic acid 4-(tert-butoxycarbonylamino-methyl)-5-{(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-2-methyl-pyridin-3-yl ester tert-butyl ester

There total 5 articles about Carbonic acid 4-(tert-butoxycarbonylamino-methyl)-5-{(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-2-methyl-pyridin-3-yl ester tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 82911-69-1
N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

: 176754-77-1
Carbonic acid 5-{(S)-2-amino-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-4-(tert-butoxycarbonylamino-methyl)-2-methyl-pyridin-3-yl ester tert-butyl ester

: 176754-78-2
Carbonic acid 4-(tert-butoxycarbonylamino-methyl)-5-{(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-2-methyl-pyridin-3-yl ester tert-butyl ester

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; at 0 - 25 ℃; for 1.5h;
DOI:10.1016/0040-4039(96)00207-9

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 176754-78-2
Carbonic acid 4-(tert-butoxycarbonylamino-methyl)-5-{(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-2-methyl-pyridin-3-yl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / 2N NaOH / dioxane / 12 h / 0 - 25 °C / pH 9.5

2: 85 percent / N-bromosuccinimide, triphenylphosphine / CH₂Cl₂ / 0.42 h / 0 - 25 °C

3: 60 percent / LDA, LiCl / tetrahydrofuran / 1.5 h / 0 °C

4: 79 percent / Na₂CO₃ / H₂O; dioxane / 1.5 h / 0 - 25 °C

With sodium hydroxide; N-Bromosuccinimide; sodium carbonate; triphenylphosphine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/0040-4039(96)00207-9

Reference yield:

: 524-36-7
pyridoxamine dihydrochloride

: 176754-78-2
Carbonic acid 4-(tert-butoxycarbonylamino-methyl)-5-{(S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[((1R,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-methyl-carbamoyl]-ethyl}-2-methyl-pyridin-3-yl ester tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / 2N NaOH / dioxane / 12 h / 0 - 25 °C / pH 9.5

2: 85 percent / N-bromosuccinimide, triphenylphosphine / CH₂Cl₂ / 0.42 h / 0 - 25 °C

3: 60 percent / LDA, LiCl / tetrahydrofuran / 1.5 h / 0 °C

4: 79 percent / Na₂CO₃ / H₂O; dioxane / 1.5 h / 0 - 25 °C

With sodium hydroxide; N-Bromosuccinimide; sodium carbonate; triphenylphosphine; lithium chloride; lithium diisopropyl amide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1016/0040-4039(96)00207-9