(2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid

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Chemical Name:(2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid
CAS No.:1140736-85-1
Molecular Formula:C₂₇H₃₇FN₄O₆
Molecular Weight:532.612
Hs Code.:

Synonyms:(2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid

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Chemical Property of (2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid

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Technology Process of (2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid

There total 1 articles about (2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1140736-94-2
(3R,5S)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-5-(methoxycarbonyl)pyrrolidin-3-yl 4-fluoroisoindoline-2-carboxylate

: 1140736-85-1
(2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid

Guidance literature:: (3R,5S)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-5-(methoxycarbonyl)pyrrolidin-3-yl 4-fluoroisoindoline-2-carboxylate; With lithium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=5;

Reference yield: 51.0%

: (1S,2S,3R,5S)-(+)-pinanediol (1R,2R)-2-(benzyloxymethyl)-1-[bis(trimethylsilyl)amino]-3-methylbutyl borate

: 1140736-85-1
(2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid

: (3R,5S)-1-((S)-2-(tert-butoxycarbonylamino)-2-cyclohexylacetyl)-5-((1R,2S)-1-(ethoxycarbonyl)-2-vinylcyclopropylcarbamoyl)pyrrolidin-3-yl 4-fluoroisoindoline-2-carboxylate

Guidance literature:: (2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 ℃; for 0.5h;

(1S,2S,3R,5S)-(+)-pinanediol (1R,2R)-2-(benzyloxymethyl)-1-[bis(trimethylsilyl)amino]-3-methylbutyl borate; With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃;

Reference yield: 43.0%

: (1S,2S,3R,5S)-(+)-pinanediol (1R,2S)-1-(bis(trimethylsilyl)amino)-2-ethyl-5-(benzyloxy)-pentyl borate

: 1140736-85-1
(2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid

: C₅₁H₇₃BFN₅O₈

Guidance literature:: (2S,4R)-1-((S)-2-(3-tert-butylureido)-2-cyclohexylacetyl)-4-(4-fluoroisoindoline-2-carbonyloxy)pyrrolidine-2-carboxylic acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 0 ℃; for 0.25h;

(1S,2S,3R,5S)-(+)-pinanediol (1R,2S)-1-(bis(trimethylsilyl)amino)-2-ethyl-5-(benzyloxy)-pentyl borate; With 4-methyl-morpholine; In dichloromethane; at 0 - 20 ℃;