(2R,3R)-1'-methyl-4-methylene-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

Base Information

Chemical Name:(2R,3R)-1'-methyl-4-methylene-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione
CAS No.:1458733-53-3
Molecular Formula:C₁₉H₁₅NO₃
Molecular Weight:305.333
Hs Code.:

Synonyms:(2R,3R)-1'-methyl-4-methylene-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

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Chemical Property of (2R,3R)-1'-methyl-4-methylene-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

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Technology Process of (2R,3R)-1'-methyl-4-methylene-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

There total 10 articles about (2R,3R)-1'-methyl-4-methylene-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: tbutyl3-phenyl-2-methylene-3-(tert-butoxycarbonyl)oxypropanoate

: 1599434-64-6
tert-butyl 1-methyl-2-oxoindolin-3-yl carbonate

: 1458733-53-3
(2R,3R)-1'-methyl-4-methylene-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

Guidance literature:: tert-butyl 2-(((tert-butoxycarbonyl)oxy)(phenyl)methyl)acrylate; tert-butyl 1-methyl-2-oxoindolin-3-yl carbonate; With 4-(3-ethyl-4-oxa-1-azatricyclo[4,4,0,0(3,8)]dec-5-yl)quinolin-6-ol; In 1,3,5-trimethyl-benzene; at 25 ℃; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; enantioselective reaction;
DOI:10.1002/ejoc.201301684

Reference yield: 92.0%

: C₂₈H₃₃NO₆

: 1458733-53-3
(2R,3R)-1'-methyl-4-methylene-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/ejoc.201301684

Reference yield:

: 956833-12-8
methyl 2-{[(tert-butoxycarbonyl)oxy](phenyl)methyl}acrylate

: 1599434-64-6
tert-butyl 1-methyl-2-oxoindolin-3-yl carbonate

: 1458733-53-3
(2R,3R)-1'-methyl-4-methylene-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

: (2S,3S)-1'-methyl-4-methylene-3-phenyl-3H-spiro[furan-2,3'-indoline]-2',5(4H)-dione

Guidance literature:: methyl 2-{[(tert-butoxycarbonyl)oxy](phenyl)methyl}acrylate; tert-butyl 1-methyl-2-oxoindolin-3-yl carbonate; With 4-(3-ethyl-4-oxa-1-azatricyclo[4,4,0,0(3,8)]dec-5-yl)quinolin-6-ol; In 1,3,5-trimethyl-benzene; at 25 ℃; Inert atmosphere;

With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; Reagent/catalyst; Overall yield = 91 %; enantioselective reaction;
DOI:10.1002/ejoc.201301684