1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl]thymine

Base Information

Chemical Name:1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl]thymine
CAS No.:883740-62-3
Molecular Formula:C₆₄H₇₀N₂O₉Si₂
Molecular Weight:1067.44
Hs Code.:

Synonyms:1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl]thymine

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Chemical Property of 1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl]thymine

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Technology Process of 1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl]thymine

There total 2 articles about 1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl]thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 883740-60-1
1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-hydroxymethyl-β-D-xylofuranosyl]thymine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 883740-62-3
1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl]thymine

Guidance literature:: With pyridine; at 20 ℃; for 12h;
DOI:10.1016/j.tet.2005.12.007

Reference yield:

: 861230-93-5
1-[2-O-acetyl-4-C-(benzoyloxymethyl)-3,5-di-O-(tert-butyldiphenylsilyl)-β-D-xylofuranosyl]thymine

: 883740-62-3
1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl]thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / NH₃ / methanol / 48 h / 20 °C

2: 97 percent / pyridine / 12 h / 20 °C

With pyridine; ammonia; In methanol;
DOI:10.1016/j.tet.2005.12.007

Reference yield: 65.0%

: 883740-62-3
1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl]thymine

: 883740-68-9
1-[5-O-(4,4'-dimethoxytrityloxy)-4-C-hydroxymethyl-α-L-ribofuranosyl]thymine

Guidance literature:: 1-[3,5-di-O-(tert-butyldiphenylsilyl)-4-C-(4,4'-dimethoxytrityloxymethyl)-β-D-xylofuranosyl]thymine; With dmap; methanesulfonyl chloride; triethylamine; In dichloromethane; at 20 ℃; for 12h;

With sodium hydroxide; In ethanol; for 16h; Heating;
DOI:10.1016/j.tet.2005.12.007