4-((2-(2-(5-isopropyl-2-methylphenylamino)-2-oxoethyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(piperidin-1-yl)propyl)benzamide

Base Information

Chemical Name:4-((2-(2-(5-isopropyl-2-methylphenylamino)-2-oxoethyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(piperidin-1-yl)propyl)benzamide
CAS No.:1602747-95-4
Molecular Formula:C₃₅H₄₃N₅O₂
Molecular Weight:565.759
Hs Code.:

Synonyms:4-((2-(2-(5-isopropyl-2-methylphenylamino)-2-oxoethyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(piperidin-1-yl)propyl)benzamide

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Chemical Property of 4-((2-(2-(5-isopropyl-2-methylphenylamino)-2-oxoethyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(piperidin-1-yl)propyl)benzamide

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Technology Process of 4-((2-(2-(5-isopropyl-2-methylphenylamino)-2-oxoethyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(piperidin-1-yl)propyl)benzamide

There total 6 articles about 4-((2-(2-(5-isopropyl-2-methylphenylamino)-2-oxoethyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(piperidin-1-yl)propyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 3529-08-6
1-(3-aminopropyl)piperidine

: 1602748-93-5
4-((2-(2-(5-isopropyl-2-methylphenylamino)-2-oxoethyl)-1H-benzo[d]imidazol-1-yl)methyl)benzoic acid

: 1602747-95-4
4-((2-(2-(5-isopropyl-2-methylphenylamino)-2-oxoethyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(piperidin-1-yl)propyl)benzamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.ejmech.2016.11.017

Reference yield: 90.0%

: 1602747-95-4
4-((2-(2-(5-isopropyl-2-methylphenylamino)-2-oxoethyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(piperidin-1-yl)propyl)benzamide

Guidance literature:: With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 13570-08-6
(1H-benzimidazol-2-yl)acetic acid

: 1602747-95-4
4-((2-(2-(5-isopropyl-2-methylphenylamino)-2-oxoethyl)-1H-benzo[d]imidazol-1-yl)methyl)-N-(3-(piperidin-1-yl)propyl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: HATU; triethylamine / acetonitrile / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 80 °C / Inert atmosphere

3: lithium hydroxide / tetrahydrofuran; water; methanol / Inert atmosphere

4: triethylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; lithium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2016.11.017