(±)-4-Hydroxyamphetamine hydrochloride (HMA)

Base Information

• Chemical Name: (±)-4-Hydroxyamphetamine hydrochloride (HMA)
• CAS No.: 876-26-6
• Molecular Formula: C9H13NO•ClH
• Molecular Weight: 187.69
• Mol file: 876-26-6.mol

Synonyms:Phenol, 4-(2-aminopropyl)-, hydrochloride;alpha-Methyltyramine hydrochloride;Phenol, p-(2-aminopropyl)-, hydrochloride;4-Hydroxyamphetamine hydrochloride;4-(2-Aminopropyl)phenol hydrochloride;α-METHYLTYRAMINE HYDROCHLORIDE;

Chemical Property of (±)-4-Hydroxyamphetamine hydrochloride (HMA)

Chemical Property:

• Melting Point: 171-172 °C
• PSA: 46.25000
• LogP: 2.78420

Purity/Quality:

p-Hydroxyamphetamine Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): A reproductive hazard.
• Hazard Codes: A reprodu
• Safety Statements: Experimental reproductive effects. When heated to decomposition it emits toxic vapors of"> x, HCl, and Cl−." target="_blank">Experimental reproductive effects. When heated to decomposition it emits toxic vapors of

MSDS Files:

SDS file from LookChem

Useful:

• Uses: p-Hydroxyamphetamine is a major metabolite of Amphetamine (A634240), a sympathomimetic and psychotropic drug which is extensively metabolized in liver and in brain.

Technology Process of (±)-4-Hydroxyamphetamine hydrochloride (HMA)

There total 1 articles about (±)-4-Hydroxyamphetamine hydrochloride (HMA) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-2-(p-methoxyphenyl)-ethylamine hydrochloride (3706-26-1,50505-81-2,52740-56-4) → 1-(4-hydroxyphenyl)propan-2-ammonium chloride (876-26-6,6078-07-5)

Guidance literature:

With hydrogenchloride; at 140 ℃; for 24h;

DOI:10.1021/jm0704595

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 1-(4-hydroxyphenyl)propan-2-ammonium chloride (876-26-6,6078-07-5) → C14H21NO3

Guidance literature:

With triethylamine; In water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1021/jm0704595

Reference yield:

tert-butyl-(3-{[tert-butyl(dimethyl)silyl]oxy}-5-oxiran-2-ylphenoxy)dimethylsilane (955952-61-1) + 1-(4-hydroxyphenyl)propan-2-ammonium chloride (876-26-6,6078-07-5) → C29H49NO4Si2

Guidance literature:

With triethylamine; In methanol; for 24h; Heating;

DOI:10.1021/jm0704595

upstream raw materials:

1-methyl-2-(p-methoxyphenyl)-ethylamine hydrochloride

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