5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-biphenyl-3-carboxylic acid ethyl ester

Base Information

Chemical Name:5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-biphenyl-3-carboxylic acid ethyl ester
CAS No.:165801-65-0
Molecular Formula:C₂₃H₂₄N₄O₃
Molecular Weight:404.469
Hs Code.:

5-[2-(8-hydroxy-7,8-dihydro-6<i>H</i>-imidazo[4,5-<i>d</i>][1,3]diazepin-3-yl)-ethyl]-biphenyl-3-carboxylic acid ethyl ester

Synonyms:5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-biphenyl-3-carboxylic acid ethyl ester

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Chemical Property of 5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-biphenyl-3-carboxylic acid ethyl ester

Chemical Property:

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Technology Process of 5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-biphenyl-3-carboxylic acid ethyl ester

There total 8 articles about 5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-biphenyl-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 165801-64-9
3-bromo-5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-benzoic acid ethyl ester

: 98-80-6
phenylboronic acid

: 165801-65-0
5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-biphenyl-3-carboxylic acid ethyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; diethylene glycol dimethyl ether; at 95 ℃; for 1.5h;
DOI:10.1021/jm990448e

Reference yield:

: 72079-77-7
6,7-dihydroimidazo<4,5-d><1,3>diazepin-8(3H)-one

: 165801-65-0
5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-biphenyl-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: NaH; NaI / dimethylformamide

2: NaBH₄ / methanol; CH₂Cl₂

3: Pd(PPh₃)4; Na₂CO₃ / ethanol; bis-(2-methoxy-ethyl) ether / 1.5 h / 95 °C

With sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydride; sodium carbonate; sodium iodide; In methanol; ethanol; dichloromethane; diethylene glycol dimethyl ether; N,N-dimethyl-formamide; 1: Alkylation / 2: Reduction / 3: Addition;
DOI:10.1021/jm990448e

Reference yield:

: 67973-33-5
3,5-dibromobenzoic acid ethyl ester

: 165801-65-0
5-[2-(8-hydroxy-7,8-dihydro-6H-imidazo[4,5-d][1,3]diazepin-3-yl)-ethyl]-biphenyl-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Pd(PPh₃)4 / dimethylformamide / 36 h / 80 °C

2: NaIO₄; RuO₂ / CCl₄; acetonitrile; H₂O / 0.25 h

3: NaBH₄ / methanol / 1 h / 20 °C

4: Ph₃P; CBr₄ / CH₂Cl₂ / 0.5 h / 0 °C

5: NaH; NaI / dimethylformamide

6: NaBH₄ / methanol; CH₂Cl₂

7: Pd(PPh₃)4; Na₂CO₃ / ethanol; bis-(2-methoxy-ethyl) ether / 1.5 h / 95 °C

With ruthenium(IV) oxide; sodium tetrahydroborate; sodium periodate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; carbon tetrabromide; sodium hydride; sodium carbonate; triphenylphosphine; sodium iodide; In methanol; tetrachloromethane; ethanol; dichloromethane; diethylene glycol dimethyl ether; water; N,N-dimethyl-formamide; acetonitrile; 1: Substitution / 2: Oxidation / 3: Reduction / 4: Bromination / 5: Alkylation / 6: Reduction / 7: Addition;
DOI:10.1021/jm990448e