(S)-4-(3-methoxyphenyl)-3-methylbutanoic acid phenyl amide

Base Information

Chemical Name:(S)-4-(3-methoxyphenyl)-3-methylbutanoic acid phenyl amide
CAS No.:1415610-43-3
Molecular Formula:C₁₈H₂₁NO₂
Molecular Weight:283.37
Hs Code.:

Synonyms:(S)-4-(3-methoxyphenyl)-3-methylbutanoic acid phenyl amide

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Chemical Property of (S)-4-(3-methoxyphenyl)-3-methylbutanoic acid phenyl amide

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Technology Process of (S)-4-(3-methoxyphenyl)-3-methylbutanoic acid phenyl amide

There total 5 articles about (S)-4-(3-methoxyphenyl)-3-methylbutanoic acid phenyl amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 2398-37-0
3-methoxyphenyl bromide

: (S)-4-trifluoroborato-3-methylbutanoic acid phenyl amide potassium salt

: 1415610-43-3
(S)-4-(3-methoxyphenyl)-3-methylbutanoic acid phenyl amide

Guidance literature:: With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate; In water; toluene; at 85 ℃; for 24h;
DOI:10.1039/c2cc36199j

Reference yield:

: 62-53-3
aniline

: 1415610-43-3
(S)-4-(3-methoxyphenyl)-3-methylbutanoic acid phenyl amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / dichloromethane / 5 h / 0 °C

1.2: 0 - 20 °C

2.1: bis(norbornadiene)rhodium(l)tetrafluoroborate; (R)-2-(2,3,4,5-tetrahydrobenzo[b]oxepin-3-yl)acetic acid tert-butyl ester / tetrahydrofuran / 20 °C

3.1: potassium hydrogen difluoride / water; acetonitrile / 0.33 h

4.1: palladium diacetate; potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 24 h / 85 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dmap; bis(norbornadiene)rhodium(l)tetrafluoroborate; potassium hydrogen difluoride; (R)-2-(2,3,4,5-tetrahydrobenzo[b]oxepin-3-yl)acetic acid tert-butyl ester; palladium diacetate; potassium carbonate; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;
DOI:10.1039/c2cc36199j

Reference yield:

: 1617-31-8
3-methylbut-3-enoic acid

: 1415610-43-3
(S)-4-(3-methoxyphenyl)-3-methylbutanoic acid phenyl amide

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / dichloromethane / 5 h / 0 °C

1.2: 0 - 20 °C

2.1: bis(norbornadiene)rhodium(l)tetrafluoroborate; (R)-2-(2,3,4,5-tetrahydrobenzo[b]oxepin-3-yl)acetic acid tert-butyl ester / tetrahydrofuran / 20 °C

3.1: potassium hydrogen difluoride / water; acetonitrile / 0.33 h

4.1: palladium diacetate; potassium carbonate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / toluene; water / 24 h / 85 °C

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dmap; bis(norbornadiene)rhodium(l)tetrafluoroborate; potassium hydrogen difluoride; (R)-2-(2,3,4,5-tetrahydrobenzo[b]oxepin-3-yl)acetic acid tert-butyl ester; palladium diacetate; potassium carbonate; In tetrahydrofuran; dichloromethane; water; toluene; acetonitrile;
DOI:10.1039/c2cc36199j