3-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3-phenyl-propylsulfanylcarbonyl]-propionic acid tert-butyl ester

Base Information

Chemical Name:3-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3-phenyl-propylsulfanylcarbonyl]-propionic acid tert-butyl ester
CAS No.:141437-91-4
Molecular Formula:C₂₇H₃₃NO₆S
Molecular Weight:499.628
Hs Code.:

Synonyms:3-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3-phenyl-propylsulfanylcarbonyl]-propionic acid tert-butyl ester

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Chemical Property of 3-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3-phenyl-propylsulfanylcarbonyl]-propionic acid tert-butyl ester

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Technology Process of 3-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3-phenyl-propylsulfanylcarbonyl]-propionic acid tert-butyl ester

There total 3 articles about 3-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3-phenyl-propylsulfanylcarbonyl]-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 15026-17-2
succinic acid mono-tert-butyl ester

: 81110-69-2
N-(2-mercaptomethyl-3-phenyl-1-oxopropyl)-glycine benzyl ester

: 141437-91-4
3-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3-phenyl-propylsulfanylcarbonyl]-propionic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; a) 0 deg C, 1 h, b) RT, overnight;
DOI:10.1021/jm00091a016

Reference yield:

: 141437-88-9
{2-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3-phenyl-propyldisulfanylmethyl]-3-phenyl-propionylamino}-acetic acid benzyl ester

: 141437-91-4
3-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3-phenyl-propylsulfanylcarbonyl]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / Zn, 1 M aq. HCl / methanol / 2 h / Ambient temperature

2: 68 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, overnight

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00091a016

Reference yield:

: 141437-87-8
2-(2-Carboxy-3-phenyl-propyldisulfanylmethyl)-3-phenyl-propionic acid

: 141437-91-4
3-[2-(Benzyloxycarbonylmethyl-carbamoyl)-3-phenyl-propylsulfanylcarbonyl]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / Et₃N, 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / Ambient temperature

2: 97 percent / Zn, 1 M aq. HCl / methanol / 2 h / Ambient temperature

3: 68 percent / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / tetrahydrofuran; CHCl₃ / a) 0 deg C, 1 h, b) RT, overnight

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; zinc; In tetrahydrofuran; methanol; chloroform;
DOI:10.1021/jm00091a016