N-{3-[2-(4-chlorophenylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-4-methyl-phenyl}-3-trifluoromethylbenzamide

Base Information

Chemical Name:N-{3-[2-(4-chlorophenylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-4-methyl-phenyl}-3-trifluoromethylbenzamide
CAS No.:1332327-74-8
Molecular Formula:C₂₈H₂₃ClF₃N₅O
Molecular Weight:537.972
Hs Code.:

Synonyms:N-{3-[2-(4-chlorophenylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-4-methyl-phenyl}-3-trifluoromethylbenzamide

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Chemical Property of N-{3-[2-(4-chlorophenylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-4-methyl-phenyl}-3-trifluoromethylbenzamide

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Technology Process of N-{3-[2-(4-chlorophenylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-4-methyl-phenyl}-3-trifluoromethylbenzamide

There total 7 articles about N-{3-[2-(4-chlorophenylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-4-methyl-phenyl}-3-trifluoromethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.2%

: 454-92-2
3-(trifluoromethyl)benzoic acid

: 1332329-42-6
[6-(5-amino-2-methyl-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-2-yl]-(4-chloro-phenyl)amine

: 1332327-74-8
N-{3-[2-(4-chlorophenylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-4-methyl-phenyl}-3-trifluoromethylbenzamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

Reference yield:

: 177-11-7
4,4-ethylenedioxy-piperidine

: 1332327-74-8
N-{3-[2-(4-chlorophenylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-4-methyl-phenyl}-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Inert atmosphere; Reflux

2: water; sulfuric acid / tetrahydrofuran / 6 h / 60 °C

3: 12 h / Reflux

4: sodium acetate / ethanol / 12 h / Reflux

5: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 12 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With sulfuric acid; water; hydrogen; sodium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;

Reference yield:

: 7745-93-9
2-bromo-4-nitrotoluene

: 1332327-74-8
N-{3-[2-(4-chlorophenylamino)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-6-yl]-4-methyl-phenyl}-3-trifluoromethylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Inert atmosphere; Reflux

2: water; sulfuric acid / tetrahydrofuran / 6 h / 60 °C

3: 12 h / Reflux

4: sodium acetate / ethanol / 12 h / Reflux

5: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 12 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 3 h / 20 °C

With sulfuric acid; water; hydrogen; sodium acetate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; palladium 10% on activated carbon; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide; toluene;