C₃₇H₃₈N₄O₇S

Base Information

• Chemical Name: C₃₇H₃₈N₄O₇S
• CAS No.: 1354578-39-4
• Molecular Formula: C₃₇H₃₈N₄O₇S
• Molecular Weight: 682.797
• Mol file: 1354578-39-4.mol

Synonyms:C₃₇H₃₈N₄O₇S

Chemical Property of C₃₇H₃₈N₄O₇S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₇H₃₈N₄O₇S

There total 16 articles about C₃₇H₃₈N₄O₇S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C38H40N4O7S (1354578-38-3) → C37H38N4O7S (1354578-39-4)

Guidance literature:

C₃₈H₄₀N₄O₇S; With ethanol; sodium hydroxide; at 20 ℃; for 2h;

With potassium hydrogensulfate; In water; ethyl acetate;

Reference yield:

Boc-D-3-cyanophenylalanine → C37H38N4O7S (1354578-39-4)

Guidance literature:

Multi-step reaction with 8 steps

1.1: hydrogen / palladium 10% on activated carbon / 40 °C

2.1: 4-methyl-morpholine / acetonitrile / Cooling with ice

3.1: dichloromethane / 1 h

4.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Reflux

4.2: 0 - 20 °C / pH 8 - 9

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / pH 7 - 8 / Cooling with ice

6.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / Cooling with ice

8.1: sodium hydroxide; ethanol / 2 h / 20 °C

With 4-methyl-morpholine; chloro-trimethyl-silane; ethanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen bromide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

(2R)-2-amino-3-(3-cyanophenyl)propanoic acid (263396-43-6) → C37H38N4O7S (1354578-39-4)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 6 h / 0 - 20 °C / pH 8 - 9

2.1: hydrogen / palladium 10% on activated carbon / 40 °C

3.1: 4-methyl-morpholine / acetonitrile / Cooling with ice

4.1: dichloromethane / 1 h

5.1: chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / Reflux

5.2: 0 - 20 °C / pH 8 - 9

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / pH 7 - 8 / Cooling with ice

7.1: hydrogen bromide; acetic acid / 1.5 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide / Cooling with ice

9.1: sodium hydroxide; ethanol / 2 h / 20 °C

With 4-methyl-morpholine; chloro-trimethyl-silane; ethanol; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen bromide; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

upstream raw materials:

benzenesulfonyl chloride

(2R)-2-amino-3-(3-cyanophenyl)propanoic acid

Boc-D-Phe(4-AMe)-OH*CH₃COOH

Boc-D-Phe(3-AMe-Cbz)-OH

Downstream raw materials:

C₂HF₃O₂*C₄₅H₄₇N₇O₆S

Refernces

• 1、 Saupe, Sebastian M.,Steinmetzer, Torsten. "A new strategy for the development of highly potent and selective plasmin inhibitors". . p. 1171 - 1180. Retrieved 2012/04/17.