(S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride

Base Information

• Chemical Name: (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride
• CAS No.: 104882-45-3
• Molecular Formula: C₁₄H₂₉NO₂*ClH
• Molecular Weight: 279.851
• Mol file: 104882-45-3.mol

Synonyms:(S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride

Chemical Property of (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride

There total 20 articles about (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(4S,5R)-4-cyclohexylmethyl-5-<(1'S)-1'-hydroxy-3-methylbutyl>oxazolidin-2-one (117161-13-4) → (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride (104882-45-3)

Guidance literature:

With hydrogenchloride; Heating;

DOI:10.1248/cpb.39.2550

Reference yield:

(4S,5R)-2,2-Dimethyl-4-(2-methylpropan-1-yl)-5-(hydroxymethyl)-1,3-dioxolane (141364-54-7) → (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride (104882-45-3)

Guidance literature:

Multi-step reaction with 4 steps

2: 1.) t-BuLi / 1.) pentane, diethyl ether, -80 to -90 deg C, 5 min, 2.) ether, r.t., 1 h

3: 64 percent / H₂ / Raney nickel / methanol / 24 h / 3040 Torr / Ambient temperature

4: 6N HCl / methanol / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; tert.-butyl lithium; nickel; In methanol;

DOI:10.1021/jo00064a013

Reference yield:

N'-[(S)-2-Cyclohexyl-1-((4R,5S)-5-isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl]-N,N-dimethyl-hydrazine (141364-53-6) → (S)-2-amino-1-cyclohexyl-(R)-3,(S)-4-dihydroxy-6-methylheptane hydrochloride (104882-45-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 64 percent / H₂ / Raney nickel / methanol / 24 h / 3040 Torr / Ambient temperature

2: 6N HCl / methanol / 4 h / Ambient temperature

With hydrogenchloride; hydrogen; nickel; In methanol;

DOI:10.1021/jo00064a013

upstream raw materials:

(S)-2-Cyclohexyl-1-((4R,5S)-5-isobutyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethylamine

(4S,5R)-4-cyclohexylmethyl-5-<(1'S)-1'-hydroxy-3-methylbutyl>oxazolidin-2-one

(4S,5R)-2,2-Dimethyl-4-(2-methylpropan-1-yl)-5-(hydroxymethyl)-1,3-dioxolane

(4S,5R)-2,2-Dimethyl-4-(2-methyl-1-propenyl)-5-(hydroxymethyl)-1,3-dioxolane

Downstream raw materials:

(2S,3R,4S)-2-<(Boc-L-α-N-methylhistidyl)amino>-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

(S)-2-{(S)-1-Benzyl-2-[4-(2-methoxy-ethoxy)-piperidin-1-yl]-2-oxo-ethylamino}-hexanoic acid ((1S,2R,3S)-1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-amide

H-histidine amide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane

N¹-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexyl)-N⁴-dimethylcarbamoylmethyl-N⁴-(1-phenyl-ethyl)-2-(1-trityl-1H-imidazol-4-ylmethyl)-succinamide