2-((S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylamino)acetic acid

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Chemical Name:2-((S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylamino)acetic acid
CAS No.:1240522-59-1
Molecular Formula:C₂₁H₂₃FN₆O₃
Molecular Weight:426.45
Hs Code.:

Synonyms:2-((S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylamino)acetic acid

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Chemical Property of 2-((S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylamino)acetic acid

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Technology Process of 2-((S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylamino)acetic acid

There total 5 articles about 2-((S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylamino)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1240522-49-9
(S)-2-amino-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide

: 298-12-4
Glyoxilic acid

: 1240522-59-1
2-((S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylamino)acetic acid

Guidance literature:: (S)-2-amino-3-(4-fluorophenyl)-N-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-yl)propanamide; Glyoxilic acid; With acetic acid; In 1,4-dioxane; 1,2-dichloro-ethane; at 70 ℃; for 0.0333333h;

With sodium tris(acetoxy)borohydride; In 1,4-dioxane; 1,2-dichloro-ethane; at 70 ℃; for 0.75h;
DOI:10.1021/ml4000854

Reference yield:

: 41153-30-4,57292-45-2,79561-25-4,129101-25-3
Boc-Phe(p-F)

: 1240522-59-1
2-((S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylamino)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 50 °C

1.2: HPLC columh / 0.75 h

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: acetic acid / 1,2-dichloro-ethane; 1,4-dioxane / 0.03 h / 70 °C

3.2: 0.75 h / 70 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/ml4000854

Reference yield:

: 1240522-47-7
4-(5-amino-1-methyl-1H-pyrazol-3-yl)-N-methylpyridin-2-amine

: 1240522-59-1
2-((S)-3-(4-fluorophenyl)-1-(1-methyl-3-(2-(methylamino)pyridin-4-yl)-1H-pyrazol-5-ylamino)-1-oxopropan-2-ylamino)acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 50 °C

1.2: HPLC columh / 0.75 h

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

3.1: acetic acid / 1,2-dichloro-ethane; 1,4-dioxane / 0.03 h / 70 °C

3.2: 0.75 h / 70 °C

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1021/ml4000854