2-(R)-isobutyl-oxirane

Base Information

• Chemical Name: 2-(R)-isobutyl-oxirane
• CAS No.: 60856-89-5
• Molecular Formula: C₆H₁₂O
• Molecular Weight: 100.161
• Mol file: 60856-89-5.mol

Synonyms:2-(R)-isobutyl-oxirane

Chemical Property of 2-(R)-isobutyl-oxirane

Chemical Property:

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(R)-isobutyl-oxirane

There total 1 articles about 2-(R)-isobutyl-oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-2-hydroxy-4-methylpentanoic acid (20312-37-2,498-36-2) → 2-(R)-isobutyl-oxirane (60856-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / LiAlH₄ / diethyl ether

2: 1.) 30percent HBr, 2.) NaOMe / 1.) AcOH, 2.) MeOH

With lithium aluminium tetrahydride; hydrogen bromide; sodium methylate; In diethyl ether;

DOI:10.1002/jlac.199619961204

Reference yield:

2-(R)-isobutyl-oxirane (60856-89-5) → C29H45NO7

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium / ethylene dibromide / 1 h / 0 °C

1.2: 16 h / 0 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 16 h / 0 - 20 °C

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 8 h / 40 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; ethylene dibromide;

DOI:10.1021/acs.orglett.9b04096

Reference yield:

2-(R)-isobutyl-oxirane (60856-89-5) → C35H50N2O9S

Guidance literature:

Multi-step reaction with 6 steps

1.1: magnesium / ethylene dibromide / 1 h / 0 °C

1.2: 16 h / 0 °C

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 16 h / 0 - 20 °C

3.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 8 h / 40 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 18 h / 0 - 20 °C

5.1: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; aluminum oxide; tert-butyl isocyanide / dichloromethane / 0.25 h

5.2: 6 h

5.3: 3 h / 0 °C

6.1: toluene-4-sulfonic acid / benzene / 4 h / 45 °C

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; dmap; aluminum oxide; tert-butyl isocyanide; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; toluene-4-sulfonic acid; magnesium; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; ethylene dibromide; benzene;

DOI:10.1021/acs.orglett.9b04096

upstream raw materials:

(R)-2-hydroxy-4-methylpentanoic acid

Downstream raw materials:

(R)-(+)-2-methyl-6-methylene-7-octen-4-ol

penaresidin B