Chemical Property of Dehydroabietic acid
Chemical Property:
- Vapor Pressure:5.53E-08mmHg at 25°C
- Melting Point:174-176 °C
- Refractive Index:1.54
- Boiling Point:425.085 °C at 760 mmHg
- PKA:4.66±0.40(Predicted)
- Flash Point:202.504 °C
- PSA：37.30000
- Density:1.059 g/cm3
- LogP:4.90490
- Storage Temp.:?20°C
- XLogP3:5.6
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:2
- Rotatable Bond Count:2
- Exact Mass:300.208930132
- Heavy Atom Count:22
- Complexity:443
- Purity/Quality:
-
98%min *data from raw suppliers
Dehydroabietic acid *data from reagent suppliers
Safty Information:
- Pictogram(s):
T,N
- Hazard Codes:T,N
- Statements:
25-50
- Safety Statements:
45-61
- MSDS Files:
-
SDS file from LookChem
Useful:
- Chemical Classes:other linear non-peptide (Diterpenoid)
- Canonical SMILES:CC(C)C1=CC2=C(C=C1)C3(CCCC(C3CC2)(C)C(=O)O)C
- Isomeric SMILES:CC(C)C1=CC2=C(C=C1)[C@]3(CCC[C@@]([C@@H]3CC2)(C)C(=O)O)C
-
General Description
Dehydroabietic acid (DHAA) is a diterpenoid compound with demonstrated pharmacological potential, acting both as a BK channel opener and an antimicrobial agent. Its derivatives, particularly those modified with nitro or (thio)urea groups on ring C, enhance BK channel-opening activity, making them promising for therapeutic applications targeting potassium channels. Additionally, DHAA-based hybrids, such as those conjugated with amino acids, exhibit potent antibacterial effects against *Staphylococcus aureus*, disrupting membrane integrity and biofilm viability at low concentrations, positioning them as candidates for novel antimicrobial therapies against Gram-positive infections.
