2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

Base Information

Chemical Name:2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydrofuran-3-yl trifluoromethanesulfonate
CAS No.:1202376-33-7
Molecular Formula:C₂₃H₁₈F₃NO₆S
Molecular Weight:493.46
Hs Code.:

Synonyms:2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

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Chemical Property of 2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

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Technology Process of 2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

There total 3 articles about 2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydrofuran-3-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4377-41-7
2-Chloromethylquinoline

: 1202376-33-7
2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 16 h / 80 °C

2: potassium tert-butylate / tetrahydrofuran / 16 h / 20 °C / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;

Reference yield:

: 1202376-28-0
ethyl 2-(4-(quinolin-2-ylmethoxy)phenyl)acetate

: 1202376-33-7
2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / tetrahydrofuran / 16 h / 20 °C / Reflux; Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With potassium tert-butylate; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 17138-28-2
(4-hydroxy-phenyl)-acetic acid ethyl ester

: 1202376-33-7
2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydrofuran-3-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / acetonitrile / 16 h / 80 °C

2: potassium tert-butylate / tetrahydrofuran / 16 h / 20 °C / Reflux; Inert atmosphere

3: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

With potassium tert-butylate; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetonitrile;