diethyl (3R,3aR,6aS)-1-benzoyl-3-butyltetrahydro-1H-furo[3,4-b]pyrrole-2,2(3H)-dicarboxylate

Base Information

Chemical Name:diethyl (3R,3aR,6aS)-1-benzoyl-3-butyltetrahydro-1H-furo[3,4-b]pyrrole-2,2(3H)-dicarboxylate
CAS No.:1391850-24-0
Molecular Formula:C₂₃H₃₁NO₆
Molecular Weight:417.502
Hs Code.:

Synonyms:diethyl (3R,3aR,6aS)-1-benzoyl-3-butyltetrahydro-1H-furo[3,4-b]pyrrole-2,2(3H)-dicarboxylate

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Chemical Property of diethyl (3R,3aR,6aS)-1-benzoyl-3-butyltetrahydro-1H-furo[3,4-b]pyrrole-2,2(3H)-dicarboxylate

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Technology Process of diethyl (3R,3aR,6aS)-1-benzoyl-3-butyltetrahydro-1H-furo[3,4-b]pyrrole-2,2(3H)-dicarboxylate

There total 6 articles about diethyl (3R,3aR,6aS)-1-benzoyl-3-butyltetrahydro-1H-furo[3,4-b]pyrrole-2,2(3H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1391850-08-0
C₂₃H₃₁NO₇

: 1391850-24-0
diethyl (3R,3aR,6aS)-1-benzoyl-3-butyltetrahydro-1H-furo[3,4-b]pyrrole-2,2(3H)-dicarboxylate

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃;
DOI:10.1002/chem.201103015

Reference yield:

: 1391849-84-5
diethyl (3R,4R,5R,1'E)-3-butyl-5-(1-hexenyl)-4-hydroxymethylpyrrolidine-2,2-dicarboxylate

: 1391850-24-0
diethyl (3R,3aR,6aS)-1-benzoyl-3-butyltetrahydro-1H-furo[3,4-b]pyrrole-2,2(3H)-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole; dmap / tetrahydrofuran / 20 °C

2.1: potassium carbonate / acetonitrile / 2 h / Reflux

2.2: 2 h / Reflux

3.1: ozone / dichloromethane / -78 °C

3.2: 1 h / -78 °C

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 20 °C

With 1H-imidazole; triethylsilane; dmap; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium carbonate; ozone; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1002/chem.201103015

Reference yield:

: 1391849-77-6
diethyl (3R,4R,5R,1'E)-3-butyl-4-formyl-5-(1-hexenyl)pyrrolidine-2,2-dicarboxylate

: 1391850-24-0
diethyl (3R,3aR,6aS)-1-benzoyl-3-butyltetrahydro-1H-furo[3,4-b]pyrrole-2,2(3H)-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium tetrahydroborate / methanol / 0.5 h / 0 °C

2.1: 1H-imidazole; dmap / tetrahydrofuran / 20 °C

3.1: potassium carbonate / acetonitrile / 2 h / Reflux

3.2: 2 h / Reflux

4.1: ozone / dichloromethane / -78 °C

4.2: 1 h / -78 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

6.1: triethylsilane; boron trifluoride diethyl etherate / dichloromethane / 20 °C

With 1H-imidazole; triethylsilane; dmap; sodium tetrahydroborate; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium carbonate; ozone; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1002/chem.201103015