isopropyl ((2S,4R)-1-acetyl-6-(4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamate hydrochloride

Base Information

Chemical Name:isopropyl ((2S,4R)-1-acetyl-6-(4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamate hydrochloride
CAS No.:1427059-15-1
Molecular Formula:C₂₆H₃₄N₄O₄*ClH
Molecular Weight:503.041
Hs Code.:

Synonyms:isopropyl ((2S,4R)-1-acetyl-6-(4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamate hydrochloride

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Chemical Property of isopropyl ((2S,4R)-1-acetyl-6-(4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamate hydrochloride

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Technology Process of isopropyl ((2S,4R)-1-acetyl-6-(4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamate hydrochloride

There total 5 articles about isopropyl ((2S,4R)-1-acetyl-6-(4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.6%

: 1403779-20-3
1-methylethyl {(2S,4R)-1-acetyl-6-[4-(2-{[2-({[(1,1-dimethylethyl)oxy]carbonyl}amino)ethyl]amino}-2-oxoethyl)phenyl]-2-methyl-1,2,3,4-tetrahydro-4-quinolinyl}carbamate

: 1427059-15-1
isopropyl ((2S,4R)-1-acetyl-6-(4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamate hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 5h;

Reference yield:

: 14062-25-0
Ethyl 4-bromophenylacetate

: 1427059-15-1
isopropyl ((2S,4R)-1-acetyl-6-(4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2.1: sodium hydroxide; water / methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 3 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

With hydrogenchloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1301198-32-2
1-methylethyl [(2S,4R)-1-acetyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydro-4-quinolinyl]carbamate

: 1427059-15-1
isopropyl ((2S,4R)-1-acetyl-6-(4-(2-((2-aminoethyl)amino)-2-oxoethyl)phenyl)-2-methyl-1,2,3,4-tetrahydroquinolin-4-yl)carbamate hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 0.5 h / 120 °C / Inert atmosphere; Microwave irradiation

2.1: sodium hydroxide; water / methanol / 20 °C

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C

3.2: 3 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

With hydrogenchloride; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;