Loxoprofen sodium

Base Information

• Chemical Name: Loxoprofen sodium
• CAS No.: 80382-23-6
• Molecular Formula: C15H17NaO3
• Molecular Weight: 268.288
• Hs Code.: 2918300090
• Mol file: 80382-23-6.mol

Synonyms:Benzeneaceticacid, a-methyl-4-[(2-oxocyclopentyl)methyl]-,sodium salt (9CI);CS 600;CS 600 (antiinflammatory);Loxonin;Loxoprofensodium;Sodium 2-[4-[(2-Oxocyclopentyl)methyl]phenyl]propionate;Sodiumloxoprofen;

Chemical Property of Loxoprofen sodium

Chemical Property:

• Vapor Pressure: 9.92E-08mmHg at 25°C
• Boiling Point: 417.9 °C at 760 mmHg
• Flash Point: 220.7 °C
• PSA: 57.20000
• LogP: 1.45170
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.5% ^*data from raw suppliers

Loxoprofen Sodium ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Loxoprofen sodium i s an antiinflammatory/analgesic agent useful in the management of rheumatoid arthritis and related disorders. It is converted in vivo to the corresponding trans-hydroxycyclopentane analog, through which it appears to exert its activity.

Technology Process of Loxoprofen sodium

There total 18 articles about Loxoprofen sodium which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.6%

loxoprofen (68767-14-6,83599-42-2,87828-34-0,87828-35-1,89675-45-6,89675-46-7,90319-65-6,90319-73-6,90319-74-7,90319-78-1,90365-02-9) → sodium 2-<4-<(2-oxocyclopentyl)methyl>phenyl>propionate (80382-23-6)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 2h; Reflux;

DOI:10.1021/jm101116s

Reference yield: 92.0%

2-[4-(bromomethyl)phenyl]propanoic acid (111128-12-2) + 2-ethoxycarbonyl-1-cyclopentanone (611-10-9) → sodium 2-<4-<(2-oxocyclopentyl)methyl>phenyl>propionate (80382-23-6)

Guidance literature:

2-[4-(bromomethyl)phenyl]propanoic acid; 2-ethoxycarbonyl-1-cyclopentanone; With sodium hydroxide; In N,N-dimethyl-formamide; for 8h; under 760.051 Torr;

With hydrogenchloride; In water; N,N-dimethyl-formamide; pH=5 - 6; Further stages;

Reference yield:

loxoprofen methyl ester (81762-92-7) → sodium 2-<4-<(2-oxocyclopentyl)methyl>phenyl>propionate (80382-23-6)

Guidance literature:

With sodium hydroxide; In ethanol; for 1h; Reflux;

upstream raw materials:

loxoprofen

1-(1-chloroethyl)-4-methylbenzene

(R,S)-2-(4'-methylphenyl) propionic acid

2-[4-(bromomethyl)phenyl]propanoic acid

Downstream raw materials:

methyl (+/-)-2-<4-(trans-2-hydroxycyclopentylmethyl)phenyl>propionate

loxoprofen methyl ester

loxoprofen

loxoprofen tolperisone salt

Refernces

• 1、 -. "New method for synthesizing loxoprofen sodium". Paragraph 0008; 0011. . Retrieved 2019/06/08.
• 2、 -. "Loxoprofen derivative". . . Retrieved 2019/01/23.