β-1'-(4-[1,3]dioxan-2-yl-3-(triisopropylsilyloxy)phenyl)-2'-desoxyribose

Base Information

Chemical Name:β-1'-(4-[1,3]dioxan-2-yl-3-(triisopropylsilyloxy)phenyl)-2'-desoxyribose
CAS No.:923571-68-0
Molecular Formula:C₂₄H₄₀O₆Si
Molecular Weight:452.663
Hs Code.:

Synonyms:β-1'-(4-[1,3]dioxan-2-yl-3-(triisopropylsilyloxy)phenyl)-2'-desoxyribose

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Chemical Property of β-1'-(4-[1,3]dioxan-2-yl-3-(triisopropylsilyloxy)phenyl)-2'-desoxyribose

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Technology Process of β-1'-(4-[1,3]dioxan-2-yl-3-(triisopropylsilyloxy)phenyl)-2'-desoxyribose

There total 5 articles about β-1'-(4-[1,3]dioxan-2-yl-3-(triisopropylsilyloxy)phenyl)-2'-desoxyribose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 887605-09-6
C₄₀H₅₂O₈Si

: 923571-68-0
β-1'-(4-[1,3]dioxan-2-yl-3-(triisopropylsilyloxy)phenyl)-2'-desoxyribose

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 2h;
DOI:10.1002/anie.200501589

Reference yield:

: 22532-62-3
4-bromosalicylaldehyde

: 923571-68-0
β-1'-(4-[1,3]dioxan-2-yl-3-(triisopropylsilyloxy)phenyl)-2'-desoxyribose

Guidance literature:: Multi-step reaction with 4 steps

1.1: 86 percent / HC(OEt)3; tetra-n-butylammonium tribromide / 72 h / 20 °C

2.1: 87 percent / EtN(i-Pr)2 / CH₂Cl₂ / 12 h / 20 °C

3.1: t-BuLi / diethyl ether; pentane / 3 h / -78 °C

3.2: CuBr*SMe₂ / diethyl ether; pentane / 0.33 h / -78 - -30 °C

3.3: 33 percent / diethyl ether; pentane; CH₂Cl₂ / -78 - 20 °C

4.1: 72 percent / K₂CO₃ / methanol / 2 h / 20 °C

With tert.-butyl lithium; tetra-N-butylammonium tribromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; orthoformic acid triethyl ester; In methanol; diethyl ether; dichloromethane; pentane;
DOI:10.1002/anie.200501589

Reference yield:

: 2-(4-bromo-2-hydroxyphenyl)-1,3-dioxane

: 923571-68-0
β-1'-(4-[1,3]dioxan-2-yl-3-(triisopropylsilyloxy)phenyl)-2'-desoxyribose

Guidance literature:: Multi-step reaction with 3 steps

1.1: 87 percent / EtN(i-Pr)2 / CH₂Cl₂ / 12 h / 20 °C

2.1: t-BuLi / diethyl ether; pentane / 3 h / -78 °C

2.2: CuBr*SMe₂ / diethyl ether; pentane / 0.33 h / -78 - -30 °C

2.3: 33 percent / diethyl ether; pentane; CH₂Cl₂ / -78 - 20 °C

3.1: 72 percent / K₂CO₃ / methanol / 2 h / 20 °C

With tert.-butyl lithium; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; diethyl ether; dichloromethane; pentane;
DOI:10.1002/anie.200501589