2-(benzyloxy)-10,10,10a-trimethyl-3,4,10,10a-tetrahydropyrimido-<1,2-a>indole

Base Information

• Chemical Name: 2-(benzyloxy)-10,10,10a-trimethyl-3,4,10,10a-tetrahydropyrimido-<1,2-a>indole
• CAS No.: 127040-17-9
• Molecular Formula: C₂₁H₂₄N₂O
• Molecular Weight: 320.434
• Mol file: 127040-17-9.mol

Synonyms:2-(benzyloxy)-10,10,10a-trimethyl-3,4,10,10a-tetrahydropyrimido-<1,2-a>indole

Chemical Property of 2-(benzyloxy)-10,10,10a-trimethyl-3,4,10,10a-tetrahydropyrimido-<1,2-a>indole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzyloxy)-10,10,10a-trimethyl-3,4,10,10a-tetrahydropyrimido-<1,2-a>indole

There total 1 articles about 2-(benzyloxy)-10,10,10a-trimethyl-3,4,10,10a-tetrahydropyrimido-<1,2-a>indole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

10,10,10a-trimethyl-1,2,3,4,10,10a-hexahydropyrimido<1,2-a>indol-2-one (93360-41-9) + benzyl chloride (100-44-7) → 2-(benzyloxy)-10,10,10a-trimethyl-3,4,10,10a-tetrahydropyrimido-<1,2-a>indole (127040-17-9) + 1-<2-(N-benzylcarbamoyl)-ethyl>-3,3-dimethyl-2-methyl-2,3-dihydro-1H-indole (127040-28-2)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

DOI:10.1007/BF00487302

Reference yield: 51.0%

2-(benzyloxy)-10,10,10a-trimethyl-3,4,10,10a-tetrahydropyrimido-<1,2-a>indole (127040-17-9) → 1-<2-(benzyloxycarbonyl)ethyl>-2,3,3-trimethyl-3H-indolium perchlorate

Guidance literature:

With perchloric acid; In ethanol; at 5 ℃;

DOI:10.1007/BF00487302

Reference yield:

2-(benzyloxy)-10,10,10a-trimethyl-3,4,10,10a-tetrahydropyrimido-<1,2-a>indole (127040-17-9) → 1-<2-(benzyloxycarbonyl)ethyl>-3,3-dimethyl-2-methylene-2,3-dihydro-1H-indole (127040-25-9)

Guidance literature:

With hydrogenchloride; sodium carbonate; Yield given. Multistep reaction; 1) acetone, 20 deg C;

DOI:10.1007/BF00487302

upstream raw materials:

10,10,10a-trimethyl-1,2,3,4,10,10a-hexahydropyrimido<1,2-a>indol-2-one

benzyl chloride

Downstream raw materials:

1-<2-(benzyloxycarbonyl)ethyl>-3,3-dimethyl-2-methylene-2,3-dihydro-1H-indole