methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

Base Information

• Chemical Name: methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate
• CAS No.: 1445789-92-3
• Molecular Formula: C₂₄H₂₁N₅O₆
• Molecular Weight: 475.461
• Mol file: 1445789-92-3.mol

Synonyms:methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

Chemical Property of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate

There total 3 articles about methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

methyl 3-hydroxy-5-nitrobenzoate (55076-32-9) + 4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide (1374867-83-0) → methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate (1445789-92-3)

Guidance literature:

methyl 3-hydroxy-5-nitrobenzoate; With palladium 10% on activated carbon; hydrogen; acetic acid; at 20 ℃;

4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide; at 20 ℃;

Reference yield:

7-bromo-4-chloroquinoline-3-carboxamide (1374867-81-8) → methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate (1445789-92-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

2.1: hydrogen; acetic acid; palladium 10% on activated carbon / 20 °C

2.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; In 1,4-dioxane; water;

Reference yield:

7-bromo-4-hydroxy-3-quinolinecarboxylic acid (860205-92-1,154326-11-1) → methyl 3-((3-carbamoyl-7-(2,4-dimethoxypyrimidin-5-yl)quinolin-4-yl)amino)-5-hydroxybenzoate (1445789-92-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trichlorophosphate / Reflux

1.2: 2 h / Cooling with ice

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,4-dioxane; water / 75 °C

3.1: hydrogen; acetic acid; palladium 10% on activated carbon / 20 °C

3.2: 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; potassium carbonate; acetic acid; trichlorophosphate; In 1,4-dioxane; water;

upstream raw materials:

7-bromo-4-chloroquinoline-3-carboxamide

7-bromo-4-hydroxy-3-quinolinecarboxylic acid

methyl 3-hydroxy-5-nitrobenzoate

4-chloro-7-(2,4-dimethoxypyrimidin-5-yl)quinoline-3-carboxamide