Biphenyl-4-carboxylic acid (S)-1-(6-chloro-2-methoxy-3-methoxymethyl-pyridin-4-yl)-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-propyl ester

Base Information

Chemical Name:Biphenyl-4-carboxylic acid (S)-1-(6-chloro-2-methoxy-3-methoxymethyl-pyridin-4-yl)-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-propyl ester
CAS No.:146596-06-7
Molecular Formula:C₄₁H₄₆ClNO₆
Molecular Weight:684.272
Hs Code.:

Biphenyl-4-carboxylic acid (S)-1-(6-chloro-2-methoxy-3-methoxymethyl-pyridin-4-yl)-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-propyl ester

Synonyms:Biphenyl-4-carboxylic acid (S)-1-(6-chloro-2-methoxy-3-methoxymethyl-pyridin-4-yl)-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-propyl ester

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Chemical Property of Biphenyl-4-carboxylic acid (S)-1-(6-chloro-2-methoxy-3-methoxymethyl-pyridin-4-yl)-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-propyl ester

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Technology Process of Biphenyl-4-carboxylic acid (S)-1-(6-chloro-2-methoxy-3-methoxymethyl-pyridin-4-yl)-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-propyl ester

There total 3 articles about Biphenyl-4-carboxylic acid (S)-1-(6-chloro-2-methoxy-3-methoxymethyl-pyridin-4-yl)-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17228-64-7
6-chloro-2-methoxypyridine

: 146596-06-7
Biphenyl-4-carboxylic acid (S)-1-(6-chloro-2-methoxy-3-methoxymethyl-pyridin-4-yl)-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) t-BuLi, 3.) n-BuLi, 4.) I₂

2: 92 percent / Et₃SIH, TFA

3: 1.) n-BuLi

With triethylsilane; n-butyllithium; iodine; tert.-butyl lithium; trifluoroacetic acid;
DOI:10.1021/ja00053a049

Reference yield:

: 144290-13-1
6-chloro-4-iodo-2-methoxy-3-pyridinecarboxaldehyde

: 146596-06-7
Biphenyl-4-carboxylic acid (S)-1-(6-chloro-2-methoxy-3-methoxymethyl-pyridin-4-yl)-1-[(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyloxycarbonyl]-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / Et₃SIH, TFA

2: 1.) n-BuLi

With triethylsilane; n-butyllithium; trifluoroacetic acid;
DOI:10.1021/ja00053a049