tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate

Base Information

Chemical Name:tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate
CAS No.:1274953-69-3
Molecular Formula:C₄₉H₉₃NO₉Si₃
Molecular Weight:924.535
Hs Code.:

tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate

Synonyms:tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate

Suppliers and Price of tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate

There total 14 articles about tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1274953-66-0
tert-butyl ((4R,6E)-4-{[tert-butyl(dimethyl)silyl]oxy}-8-oxooct-6-en-1-yl)carbamate

: 1274953-67-1
(3S,5S)-3,5-bis-(tert-butyldimethylsilanyloxy)-7-(4-methoxy-benzyloxy)-heptane-1-al

: 1275575-88-6
N,N,N-tributylbutan-1-aminium trifluoro(propa-1,2-dien-1-yl)borate

: 1274953-69-3
tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate

Guidance literature:: N,N,N-tributylbutan-1-aminium trifluoro(propa-1,2-dien-1-yl)borate; With chloro-trimethyl-silane; lithium (S)-B-H₂-⁽¹⁰⁾-trimethylsilyl-9-borabicyclo[3.3.2]decane; In dichloromethane; toluene; at -78 - -30 ℃; Inert atmosphere;

(3S,5S)-3,5-bis-(tert-butyldimethylsilanyloxy)-7-(4-methoxy-benzyloxy)-heptane-1-al; In dichloromethane; toluene; at -78 ℃; for 4h; Inert atmosphere;

tert-butyl ((4R,6E)-4-{[tert-butyl(dimethyl)silyl]oxy}-8-oxooct-6-en-1-yl)carbamate; Further stages;
DOI:10.1016/j.tet.2011.06.008

Reference yield:

: C₆₁H₁₁₆BNO₉Si₄

: 1274953-69-3
tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate

Guidance literature:: With potassium dihydrogenphosphate; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; toluene; at 20 ℃; for 24h; pH=7; optical yield given as %de; Inert atmosphere;
DOI:10.1021/ol2003836

Reference yield:

: 1274953-79-5
(3S,5S)-1-(4-methoxy-benzyloxy)-oct-7-ene-3,5-diol

: 1274953-69-3
tert-butyl {(4R,6E,8R,10E,12R,14S,16S)-4,14,16-tris{[tert-butyl(dimethyl)silyl]oxy}-8,12-dihydroxy-18-[(4-methoxybenzyl)-oxy]octadeca-6,10-dien-1-yl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

2: 2,6-dimethylpyridine; sodium periodate; osmium(VIII) oxide / 1,4-dioxane; water; tert-butyl alcohol / 5 h / Inert atmosphere

3: diethyl ether; dichloromethane; toluene / 4 h / -78 °C / Inert atmosphere

4: boron trifluoride diethyl etherate / diethyl ether; dichloromethane; toluene / 4 h / -78 °C / Inert atmosphere

5: potassium dihydrogenphosphate; sodium hydroxide / tetrahydrofuran; methanol; dichloromethane; water; toluene / 24 h / 20 °C / pH 7 / Inert atmosphere

With 1H-imidazole; 2,6-dimethylpyridine; sodium periodate; potassium dihydrogenphosphate; osmium(VIII) oxide; boron trifluoride diethyl etherate; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;
DOI:10.1021/ol2003836