7,8-dimethoxy-2-methyl-4-(4'-methylphenyl)-1,2-dihydro-3H-2-benzazepin-3-one

Base Information

Chemical Name:7,8-dimethoxy-2-methyl-4-(4'-methylphenyl)-1,2-dihydro-3H-2-benzazepin-3-one
CAS No.:267669-26-1
Molecular Formula:C₂₀H₂₁NO₃
Molecular Weight:323.392
Hs Code.:

Synonyms:7,8-dimethoxy-2-methyl-4-(4'-methylphenyl)-1,2-dihydro-3H-2-benzazepin-3-one

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Chemical Property of 7,8-dimethoxy-2-methyl-4-(4'-methylphenyl)-1,2-dihydro-3H-2-benzazepin-3-one

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Technology Process of 7,8-dimethoxy-2-methyl-4-(4'-methylphenyl)-1,2-dihydro-3H-2-benzazepin-3-one

There total 8 articles about 7,8-dimethoxy-2-methyl-4-(4'-methylphenyl)-1,2-dihydro-3H-2-benzazepin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 267669-11-4
C₂₀H₂₁NO₃

: 267669-26-1
7,8-dimethoxy-2-methyl-4-(4'-methylphenyl)-1,2-dihydro-3H-2-benzazepin-3-one

Guidance literature:: With potassium hydroxide; In methanol; at 20 ℃;
DOI:10.1021/ol0056832

Reference yield: 76.0%

: 267669-11-4
({4',5'-dimethoxy-2'-[3-(4'-methylphenyl)but-2-ynyl]phenyl}methylene)methylamine N-oxide

: 267669-26-1
7,8-dimethoxy-2-methyl-4-(4'-methylphenyl)-1,2-dihydro-3H-2-benzazepin-3-one

: 1-(5',6'-dimethoxy-2'-methyl-2'H-isoindol-1'-yl)-2-(4-methylphenyl)ethan-1-one

Guidance literature:: With potassium hydroxide; In methanol; at 20 ℃; for 5h;
DOI:10.1002/1099-0690(200109)2001:17<3313::AID-EJOC3313>3.0.CO;2-E

Reference yield:

: 103477-58-3
2-(2-bromo-4,5-dimethoxyphenyl)-1,3-dioxolane

: 267669-26-1
7,8-dimethoxy-2-methyl-4-(4'-methylphenyl)-1,2-dihydro-3H-2-benzazepin-3-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: MgBr₂ / diethyl ether; tetrahydrofuran / -78 - 20 °C

1.2: 64 percent / diethyl ether; tetrahydrofuran / 2 h / Heating

2.1: 72 percent / Bu₄NHSO₄; KF; NH₄Cl / CH₂Cl₂ / 18 h / 20 °C

3.1: 63 percent / PdCl₂(PPh₃)2; CuI; triethylamine / 50 h / 20 °C

4.1: 82 percent / PTSA; water / acetone / 3 h / Heating

5.1: 87 percent / sodium acetate / CH₂Cl₂ / 6 h / 20 °C

6.1: 76 percent / KOH / methanol / 5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium fluoride; potassium hydroxide; copper(l) iodide; water; sodium acetate; tetra(n-butyl)ammonium hydrogensulfate; ammonium chloride; toluene-4-sulfonic acid; triethylamine; magnesium bromide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetone;
DOI:10.1002/1099-0690(200109)2001:17<3313::AID-EJOC3313>3.0.CO;2-E