[(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetyl chloride

Base Information

Chemical Name:[(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetyl chloride
CAS No.:92685-97-7
Molecular Formula:C₂₂H₃₄ClNO₅Si
Molecular Weight:456.054
Hs Code.:

Synonyms:[(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetyl chloride

Suppliers and Price of [(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetyl chloride

There total 14 articles about [(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80829-72-7
<3S-<3α(S^*),4β>>-t-butyl 1-(2,4-dimethoxybenzyl)-3-(1-hydroxyethyl)-2-azetidinone-4-carboxylate

: 92685-97-7
[(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetyl chloride

Guidance literature:: Multi-step reaction with 6 steps

1: CF₃COOH / CH₂Cl₂

2: dimethylformamide; acetic acid / 0.08 h / 60 °C

3: 4-dimethylaminopyridine / dimethylformamide / 16 h / Ambient temperature

4: 37.3 percent / trimethylsilyl trifluoromethanesulphonate / CH₂Cl₂ / 16 h / 20 °C

5: 96 percent / H₂ / 10percent palladium / ethyl acetate

6: oxalyl chloride / tetrahydrofuran / 12 h / Ambient temperature

With dmap; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; hydrogen; trifluoroacetic acid; palladium; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91132-9

Reference yield:

: 81902-59-2
(2S,3R)-N-(2,4-dimethoxybenzyl)-N-(t-butoxycarbonylmethyl)-2-bromo-3-hydroxybutyramide

: 92685-97-7
[(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetyl chloride

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) LiN(SiMe₃)2, 2.) LiN(SiMe₃)2 / 1.) THF, 15 min., from 0 deg C to 5 deg C, 2.) from 20 deg C to 25 deg C, THF, 1 h.

2: CF₃COOH / CH₂Cl₂

3: dimethylformamide; acetic acid / 0.08 h / 60 °C

4: 4-dimethylaminopyridine / dimethylformamide / 16 h / Ambient temperature

5: 37.3 percent / trimethylsilyl trifluoromethanesulphonate / CH₂Cl₂ / 16 h / 20 °C

6: 96 percent / H₂ / 10percent palladium / ethyl acetate

7: oxalyl chloride / tetrahydrofuran / 12 h / Ambient temperature

With dmap; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; hydrogen; trifluoroacetic acid; lithium hexamethyldisilazane; palladium; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91132-9

Reference yield:

: 81902-60-5
t-butyl N-(2,4-dimethoxybenzyl)glycinate

: 92685-97-7
[(2R,3S)-3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-1-(2,4-dimethoxy-benzyl)-4-oxo-azetidin-2-yl]-acetyl chloride

Guidance literature:: Multi-step reaction with 8 steps

1: 84 percent / N,N-dicyclohexylcarbodiimide / tetrahydrofuran / 0.25 h / 20 - 25 °C

2: 1.) LiN(SiMe₃)2, 2.) LiN(SiMe₃)2 / 1.) THF, 15 min., from 0 deg C to 5 deg C, 2.) from 20 deg C to 25 deg C, THF, 1 h.

3: CF₃COOH / CH₂Cl₂

4: dimethylformamide; acetic acid / 0.08 h / 60 °C

5: 4-dimethylaminopyridine / dimethylformamide / 16 h / Ambient temperature

6: 37.3 percent / trimethylsilyl trifluoromethanesulphonate / CH₂Cl₂ / 16 h / 20 °C

7: 96 percent / H₂ / 10percent palladium / ethyl acetate

8: oxalyl chloride / tetrahydrofuran / 12 h / Ambient temperature

With dmap; oxalyl dichloride; trimethylsilyl trifluoromethanesulfonate; hydrogen; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium hexamethyldisilazane; palladium; In tetrahydrofuran; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91132-9