C₁₉H₁₇N₃O

Base Information

• Chemical Name: C₁₉H₁₇N₃O
• CAS No.: 1609243-83-5
• Molecular Formula: C₁₉H₁₇N₃O
• Molecular Weight: 303.363
• Mol file: 1609243-83-5.mol

Synonyms:C₁₉H₁₇N₃O

Chemical Property of C₁₉H₁₇N₃O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₁₇N₃O

There total 3 articles about C₁₉H₁₇N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

C19H19NO (1609244-36-1) → C19H17N3O (1609243-83-5)

Guidance literature:

With 2-Methyl-2-nitropropane; trimethylsilylazide; In acetonitrile; at 0 ℃; for 1h; Inert atmosphere;

DOI:10.1002/anie.201308611

Reference yield:

1-(2-phenylethynyl)-1-cyclobutanol (308805-77-8) → C19H17N3O (1609243-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

2: 2-Methyl-2-nitropropane; trimethylsilylazide / acetonitrile / 1 h / 0 °C / Inert atmosphere

With 2-Methyl-2-nitropropane; trimethylsilylazide; tetrabutyl-ammonium chloride; palladium diacetate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In N,N-dimethyl-formamide; acetonitrile; 1: |Heck Reaction;

DOI:10.1002/anie.201308611

Reference yield:

phenylethynylmagnesium bromide (6738-06-3) → C19H17N3O (1609243-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: cerium(III) chloride / tetrahydrofuran / 1 h / -78 °C / Schlenk technique

1.2: 6 h / -78 - 25 °C / Schlenk technique; Inert atmosphere

2.1: tetrabutyl-ammonium chloride; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium diacetate / N,N-dimethyl-formamide / 12 h / 80 °C / Inert atmosphere

3.1: 2-Methyl-2-nitropropane; trimethylsilylazide / acetonitrile / 1 h / 0 °C / Inert atmosphere

With cerium(III) chloride; 2-Methyl-2-nitropropane; trimethylsilylazide; tetrabutyl-ammonium chloride; palladium diacetate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 2.1: |Heck Reaction;

DOI:10.1002/anie.201308611

upstream raw materials:

1-(2-phenylethynyl)-1-cyclobutanol

C₁₉H₁₉NO

phenylethynylmagnesium bromide

Downstream raw materials:

3-methyl-10-phenyl-8,9-dihydropyrido[1,2-a]indol-6(7H)-one