tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate

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Chemical Name:tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate
CAS No.:1009736-88-2
Molecular Formula:C₃₁H₄₉IN₄O₇
Molecular Weight:716.657
Hs Code.:

tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate

Synonyms:tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate

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Chemical Property of tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate

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Technology Process of tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate

There total 7 articles about tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (S,Z)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(5-(2-iodovinyl)-2,4-dimethoxyphenyl)propanoic acid

: (2S,3S)-2-amino-N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-3-methylpentanamide hydrochloride

: 1009736-88-2
tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:: (S,Z)-2-((tert-butoxycarbonyl)(methyl)amino)-3-(5-(2-iodovinyl)-2,4-dimethoxyphenyl)propanoic acid; With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

(2S,3S)-2-amino-N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-3-methylpentanamide hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/acs.orglett.8b03475

Reference yield: 50.0%

: 1009736-93-9
C₃₀H₄₈N₄O₈

: 3020-28-8
(iodomethyl)triphenylphosphonium iodide

: 1009736-88-2
tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;
DOI:10.1055/s-2007-1000833

Reference yield:

: tert-butyl (S)-(3-(5-formyl-2,4-dimethoxyphenyl)-1-oxo-1-(quinolin-8-ylamino)propan-2-yl)(methyl)carbamate

: 1009736-88-2
tert-butyl ((S)-1-(((2S,3S)-1-(((S)-1-amino-4-methyl-1-oxopentan-2-yl)amino)-3-methyl-1-oxopentan-2-yl)amino)-3-(5-((Z)-2-iodovinyl)-2,4-dimethoxyphenyl)-1-oxopropan-2-yl)(methyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.33 h / 20 °C

1.2: 8 h / -78 °C

2.1: di-tert-butyl dicarbonate; dmap / acetonitrile / 20 °C

2.2: 3 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / N,N-dimethyl-formamide / 0.5 h / 0 °C

3.2: 0 - 20 °C

With dmap; di-tert-butyl dicarbonate; sodium hexamethyldisilazane; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.orglett.8b03475