2-chloro-2-cyclopentyl-N-[5-(2-fluoro-phenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazol-4-yl]-acetamide

Base Information

• Chemical Name: 2-chloro-2-cyclopentyl-N-[5-(2-fluoro-phenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazol-4-yl]-acetamide
• CAS No.: 351350-36-2
• Molecular Formula: C₂₂H₂₂ClFN₄OS
• Molecular Weight: 444.96

Synonyms:2-chloro-2-cyclopentyl-N-[5-(2-fluoro-phenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazol-4-yl]-acetamide

Chemical Property of 2-chloro-2-cyclopentyl-N-[5-(2-fluoro-phenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazol-4-yl]-acetamide

Chemical Property:

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Technology Process of 2-chloro-2-cyclopentyl-N-[5-(2-fluoro-phenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazol-4-yl]-acetamide

There total 3 articles about 2-chloro-2-cyclopentyl-N-[5-(2-fluoro-phenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazol-4-yl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2-bromocyclopentylacetylchloride (99644-87-8) + 5-(2-Fluorophenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazolo-4-ylamine (252369-25-8) → 2-chloro-2-cyclopentyl-N-[5-(2-fluoro-phenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazol-4-yl]-acetamide (351350-36-2)

Guidance literature:

With pyridine; In N,N-dimethyl-formamide; at 0 ℃;

DOI:10.1055/s-2001-13354

Reference yield:

2-fluorophenyl acetonitrile (326-62-5) → 2-chloro-2-cyclopentyl-N-[5-(2-fluoro-phenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazol-4-yl]-acetamide (351350-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 29 percent / K₂CO₃ / dimethylsulfoxide / 16 h / 20 °C

2: 77 percent / pyridine / dimethylformamide / 0 °C

With pyridine; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1055/s-2001-13354

Reference yield:

azidomethyl phenyl sulphide (77422-70-9) → 2-chloro-2-cyclopentyl-N-[5-(2-fluoro-phenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazol-4-yl]-acetamide (351350-36-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 29 percent / K₂CO₃ / dimethylsulfoxide / 16 h / 20 °C

2: 77 percent / pyridine / dimethylformamide / 0 °C

With pyridine; potassium carbonate; In dimethyl sulfoxide; N,N-dimethyl-formamide;

DOI:10.1055/s-2001-13354

upstream raw materials:

2-bromocyclopentylacetylchloride

5-(2-Fluorophenyl)-3-phenylsulfanylmethyl-3H-[1,2,3]triazolo-4-ylamine

2-fluorophenyl acetonitrile

azidomethyl phenyl sulphide

Downstream raw materials:

6-cyclopentyl-3-(2-fluoro-phenyl)-4H-[1,2,3]triazolo[1,5-a]pyrimidin-5-one

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