Technology Process of 3-[(R)-hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethyl)pyridin-2-yl]-cyclobutanone
There total 4 articles about 3-[(R)-hydroxy(pyridin-2-yl)methyl]-3-[4-(trifluoromethyl)pyridin-2-yl]-cyclobutanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / toluene / 2 h / 20 °C / Reflux
2.1: potassium hexamethylsilazane / toluene / 4 h / 60 °C
3.1: n-butyllithium / diethyl ether / 1 h / -78 °C
3.2: 2 h / -78 °C
4.1: methanol; sodium tetrahydroborate / dichloromethane / 1 h / 20 °C
5.1: hydrogenchloride / acetone / 20 °C
6.1: Column: AD-H / isopropyl alcohol; diethylamine; carbon dioxide / Resolution of racemate; liquid CO2
With
hydrogenchloride; methanol; sodium tetrahydroborate; n-butyllithium; potassium hexamethylsilazane; toluene-4-sulfonic acid;
In
diethyl ether; dichloromethane; carbon dioxide; diethylamine; isopropyl alcohol; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: toluene-4-sulfonic acid / toluene / 2 h / 20 °C / Reflux
2.1: potassium hexamethylsilazane / toluene / 4 h / 60 °C
3.1: n-butyllithium / diethyl ether / 1 h / -78 °C
3.2: 2 h / -78 °C
3.3: 0.5 h / -78 - 20 °C
4.1: methanol; sodium tetrahydroborate / dichloromethane / 1 h / 20 °C
5.1: hydrogenchloride / acetone / 20 °C
6.1: chiral column Column: AD-H / Resolution of racemate
With
hydrogenchloride; methanol; sodium tetrahydroborate; n-butyllithium; potassium hexamethylsilazane; toluene-4-sulfonic acid;
In
diethyl ether; dichloromethane; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium periodate; ruthenium(III) chloride trihydrate / dichloromethane; acetonitrile; water / 0 - 10 °C
2.1: toluene / Reflux
3.1: potassium hexamethylsilazane / toluene / 4 h / 60 °C
4.1: n-butyllithium / diethyl ether / 1 h / -78 °C
4.2: 2 h / -78 °C
5.1: methanol; sodium tetrahydroborate / dichloromethane / 1 h / 20 °C
6.1: hydrogenchloride / acetone / 20 °C
7.1: Column: AD-H / isopropyl alcohol; diethylamine; carbon dioxide / Resolution of racemate; liquid CO2
With
hydrogenchloride; methanol; sodium tetrahydroborate; sodium periodate; n-butyllithium; ruthenium(III) chloride trihydrate; potassium hexamethylsilazane;
In
diethyl ether; dichloromethane; carbon dioxide; water; diethylamine; isopropyl alcohol; acetone; toluene; acetonitrile;
