2-(5-(4-(2,6-dichlorobenzyloxy)phenyl)-3-(ethoxycarbonyl)thiophen-2-ylamino)-2-oxoacetic acid

Base Information

Chemical Name:2-(5-(4-(2,6-dichlorobenzyloxy)phenyl)-3-(ethoxycarbonyl)thiophen-2-ylamino)-2-oxoacetic acid
CAS No.:1334931-64-4
Molecular Formula:C₂₂H₁₇Cl₂NO₆S
Molecular Weight:494.352
Hs Code.:

Synonyms:2-(5-(4-(2,6-dichlorobenzyloxy)phenyl)-3-(ethoxycarbonyl)thiophen-2-ylamino)-2-oxoacetic acid

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Chemical Property of 2-(5-(4-(2,6-dichlorobenzyloxy)phenyl)-3-(ethoxycarbonyl)thiophen-2-ylamino)-2-oxoacetic acid

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Technology Process of 2-(5-(4-(2,6-dichlorobenzyloxy)phenyl)-3-(ethoxycarbonyl)thiophen-2-ylamino)-2-oxoacetic acid

There total 6 articles about 2-(5-(4-(2,6-dichlorobenzyloxy)phenyl)-3-(ethoxycarbonyl)thiophen-2-ylamino)-2-oxoacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1334931-87-1
ethyl 5-(4-(2,6-dichlorobenzyloxy)phenyl)-2-(2-ethoxy-2-oxoacetamido)thiophene-3-carboxylate

: 1334931-64-4
2-(5-(4-(2,6-dichlorobenzyloxy)phenyl)-3-(ethoxycarbonyl)thiophen-2-ylamino)-2-oxoacetic acid

Guidance literature:: ethyl 5-(4-(2,6-dichlorobenzyloxy)phenyl)-2-(2-ethoxy-2-oxoacetamido)thiophene-3-carboxylate; With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 1h;

With hydrogenchloride; In water; pH=3 - 4; chemoselective reaction;
DOI:10.1016/j.ejmech.2011.05.018

Reference yield:

: 1334930-83-4
2-(4-(2,6-dichlorobenzyloxy)phenyl)ethanol

: 1334931-64-4
2-(5-(4-(2,6-dichlorobenzyloxy)phenyl)-3-(ethoxycarbonyl)thiophen-2-ylamino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium bromite trihydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate / dichloromethane; water / 0.5 h / 0 - 20 °C / pH 8.6

2.1: sulfur; triethylamine / ethanol / 60 °C

3.1: dichloromethane / 20 °C

4.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C

4.2: pH 3 - 4

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium bromite trihydrate; sodium hydrogencarbonate; sulfur; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1016/j.ejmech.2011.05.018

Reference yield:

: 1334930-94-7
ethyl 5-(4-(2,6-dichlorobenzyloxy)phenyl)-2-aminothiophene-3-carboxylate

: 1334931-64-4
2-(5-(4-(2,6-dichlorobenzyloxy)phenyl)-3-(ethoxycarbonyl)thiophen-2-ylamino)-2-oxoacetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dichloromethane / 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 1 h / 20 °C

2.2: pH 3 - 4

With sodium hydroxide; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2011.05.018