1,1-Diphenylpropan-2-amine

Base Information

• Chemical Name: 1,1-Diphenylpropan-2-amine
• CAS No.: 3139-55-7
• Molecular Formula: C15H17N
• Molecular Weight: 211.307
• Hs Code.: 2921499090
• NSC Number: 17143
• DSSTox Substance ID: DTXSID301296918
• Nikkaji Number: J69.591B
• ChEMBL ID: CHEMBL10621
• Mol file: 3139-55-7.mol

Synonyms:1,1-diphenylpropan-2-amine;3139-55-7;DPA 1;1,1-Diphenyl-2-aminopropane;alpha-Methyl-beta-phenylbenzeneethanamine;NSC 17143;alpha-Methyl-beta-phenyl-phenethylamine;Benzeneethanamine, alpha-methyl-beta-phenyl-;Phenethylamine, alpha-methyl-beta-phenyl-;(S)-(-)-1 1-DIPHENYL-2-AMINOPROPANE 97;DPA-1;CHEMBL10621;SCHEMBL1168170;DTXSID301296918;2,4-D-SODIUMSALTMONOHYDRATE;NSC17143;BBL025144;NSC-17143;STL356040;AKOS000132637;SB47160;SB47285;LS-103659;FT-0773797;EN300-33173;AB01002493-01;2-(1,3-BENZOTHIAZOL-2-YLMETHYL)BENZOICACID;Benzeneethanamine, alpha-methyl-beta-phenyl- (9CI)

Chemical Property of 1,1-Diphenylpropan-2-amine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 78-82 °C(lit.)
• Refractive Index: 1.575
• Boiling Point: 324.161 °C at 760 mmHg
• PKA: 9.21±0.10(Predicted)
• Flash Point: 150.039 °C
• PSA: 26.02000
• Density: 1.022 g/cm³
• LogP: 3.86600
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 211.136099547
• Heavy Atom Count: 16
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

1,1-DIPHENYLPROPAN-2-AMINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C(C1=CC=CC=C1)C2=CC=CC=C2)N

Technology Process of 1,1-Diphenylpropan-2-amine

There total 10 articles about 1,1-Diphenylpropan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1,1-diphenylacetone (781-35-1) → 1,1-diphenylisopropylamine (3139-55-7)

Guidance literature:

With ammonia; hydrogen; In tetrahydrofuran; at 120 ℃; for 20h;

DOI:10.1126/science.aan6245

Reference yield: 86.0%

1,1-diphenyl-1-propene (778-66-5) → 1,1-diphenylisopropylamine (3139-55-7)

Guidance literature:

With 10-phenyl-9-(2,4,6-trimethylphenyl)acridinium tetrafluoroborate; ammonium carbonate; 2-amino-benzenethiol; In dichloromethane; chlorobenzene; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

DOI:10.1002/anie.202016679

Reference yield: 77.0%

benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) + (±)-trans-2-phenyl-cyclopropylaminehydrochloride → 1,1-diphenylisopropylamine (3139-55-7)

Guidance literature:

With trifluorormethanesulfonic acid; at 25 ℃; Mechanism; Inert atmosphere;

DOI:10.1021/jo4016198

upstream raw materials:

1,1-diphenyl-1-propene

1,1-diphenylacetone

2-chloro-1-methyl-2-phenyl-ethylamine; hydrochloride

benzene

Downstream raw materials:

1-(1-Methyl-2,2-diphenyl-ethyl)-pyrrolidine-2,5-dione

(S)-1,1-diphenyl-2-aminopropane

(R)-1,1-diphenyl-2-aminopropane

(5R,6S,10bR)-5-Methyl-6-phenyl-1,5,6,10b-tetrahydro-2H-pyrrolo[2,1-a]isoquinolin-3-one

Refernces

• 1、 Jagadeesh, Rajenahally V.,Murugesan, Kathiravan,Alshammari, Ahmad S.,Neumann, Helfried,Pohl, Marga-Martina,Radnik, J?rg,Beller, Matthias. "MOF-derived cobalt nanoparticles catalyze a general synthesis of amines". . p. 326 - 332. Retrieved 2017/09/28.
• 2、 Nilsson Lill, Sten O.,Naredla, Rajasekhar Reddy,Zielinski, Matthew E.,Knoecer, Larecia,Klumpp, Douglas A.. "Dicationic ring-opening reactions of trans -2- phenylcyclopropylamine·HCl: Electrophilic cleavage of the distal (C 2-C3) bond of cyclopropanes". . p. 8922 - 8926. Retrieved 2013/09/24.