(4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl-(2S,3R,4E)-3-hydroxy-2-palmitamidooctadec-4-enyl hydrogen phosphate

Base Information

Chemical Name:(4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl-(2S,3R,4E)-3-hydroxy-2-palmitamidooctadec-4-enyl hydrogen phosphate
CAS No.:1196665-02-7
Molecular Formula:C₄₇H₇₆BrN₂O₉P
Molecular Weight:924.006
Hs Code.:

Synonyms:(4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl-(2S,3R,4E)-3-hydroxy-2-palmitamidooctadec-4-enyl hydrogen phosphate

Suppliers and Price of (4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl-(2S,3R,4E)-3-hydroxy-2-palmitamidooctadec-4-enyl hydrogen phosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl-(2S,3R,4E)-3-hydroxy-2-palmitamidooctadec-4-enyl hydrogen phosphate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl-(2S,3R,4E)-3-hydroxy-2-palmitamidooctadec-4-enyl hydrogen phosphate

There total 12 articles about (4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl-(2S,3R,4E)-3-hydroxy-2-palmitamidooctadec-4-enyl hydrogen phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1492-30-4
4-nitrophenyl palmitate

: 1196665-01-6
(2S,3R,4E)-2-amino-3-hydroxyoctadec-4-enyl-(4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl hydrogen phosphate

: 1196665-02-7
(4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl-(2S,3R,4E)-3-hydroxy-2-palmitamidooctadec-4-enyl hydrogen phosphate

Guidance literature:: With potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; for 48h;
DOI:10.1021/jo902076w

Reference yield:

: 123-78-4
(2S,3R,4E)-2-amino-4-octadecene-1,3-diol

: 1196665-02-7
(4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl-(2S,3R,4E)-3-hydroxy-2-palmitamidooctadec-4-enyl hydrogen phosphate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / water / 20 °C

2.1: 1H-imidazole / dichloromethane / 3 h / 20 °C

2.2: 0.5 h / Reflux

2.3: 6 h / 20 °C

3.1: 1H-tetrazole / acetonitrile / 3 h / 20 °C

4.1: di-tert-butyl peroxide / toluene / 1 h / 20 °C

5.1: lithium iodide / pyridine / Reflux

6.1: hydrogenchloride / dichloromethane; methanol / 2.5 h / 50 - 60 °C

7.1: potassium carbonate / dichloromethane; N,N-dimethyl-formamide / 48 h

With 1H-imidazole; 1H-tetrazole; hydrogenchloride; di-tert-butyl peroxide; potassium carbonate; sodium hydroxide; lithium iodide; In pyridine; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 5367-32-8
5-methoxy-2-nitrotoluene

: 1196665-02-7
(4'-bromo-5'-hydroxy-2'-nitrophenyl)(phenyl)methyl-(2S,3R,4E)-3-hydroxy-2-palmitamidooctadec-4-enyl hydrogen phosphate

Guidance literature:: Multi-step reaction with 9 steps

1.1: N-Bromosuccinimide / acetonitrile / 140 °C / Pressure tube, sealed

2.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / 16 h / 140 °C

2.2: 8 h / 0 °C

3.1: tetrahydrofuran / -78 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 °C / Inert atmosphere

5.1: 1H-tetrazole / acetonitrile / 3 h / 20 °C

6.1: di-tert-butyl peroxide / toluene / 1 h / 20 °C

7.1: lithium iodide / pyridine / Reflux

8.1: hydrogenchloride / dichloromethane; methanol / 2.5 h / 50 - 60 °C

9.1: potassium carbonate / dichloromethane; N,N-dimethyl-formamide / 48 h

With 1H-tetrazole; hydrogenchloride; N-Bromosuccinimide; di-tert-butyl peroxide; potassium carbonate; N,N-dimethyl-formamide dimethyl acetal; N-ethyl-N,N-diisopropylamine; lithium iodide; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;