(2R)-N-(4-benzyloxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexyl-methylthiopropanamide

Base Information

Chemical Name:(2R)-N-(4-benzyloxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexyl-methylthiopropanamide
CAS No.:219625-12-4
Molecular Formula:C₂₉H₄₀N₂O₄S
Molecular Weight:512.714
Hs Code.:

Synonyms:(2R)-N-(4-benzyloxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexyl-methylthiopropanamide

Suppliers and Price of (2R)-N-(4-benzyloxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexyl-methylthiopropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R)-N-(4-benzyloxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexyl-methylthiopropanamide

Chemical Property:

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Technology Process of (2R)-N-(4-benzyloxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexyl-methylthiopropanamide

There total 5 articles about (2R)-N-(4-benzyloxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexyl-methylthiopropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 219625-12-4
(2R)-N-(4-benzyloxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexyl-methylthiopropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 621 g / NaOH; Bu₄NI / ethanol / 1 h

2: HOBt; EDC / CH₂Cl₂

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; dichloromethane;
DOI:10.1016/S0968-0896(02)00558-8

Reference yield:

: 2550-36-9
Cyclohexylmethyl bromide

: 219625-12-4
(2R)-N-(4-benzyloxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexyl-methylthiopropanamide

Guidance literature:: Multi-step reaction with 3 steps

1: NaOH; Bu₄NI / ethanol; H₂O / 72 h

2: 621 g / NaOH; Bu₄NI / ethanol / 1 h

3: HOBt; EDC / CH₂Cl₂

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; dichloromethane; water;
DOI:10.1016/S0968-0896(02)00558-8

Reference yield:

: 473421-00-0
(R)-2-Amino-3-cyclohexylmethylsulfanyl-propionic acid

: 219625-12-4
(2R)-N-(4-benzyloxybenzyl)-2-t-butoxycarbonylamino-3-cyclohexyl-methylthiopropanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 621 g / NaOH; Bu₄NI / ethanol / 1 h

2: HOBt; EDC / CH₂Cl₂

With sodium hydroxide; tetra-(n-butyl)ammonium iodide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In ethanol; dichloromethane;
DOI:10.1016/S0968-0896(02)00558-8