(S)-2-(1-((4-chloro-2-cyanoquinolin-7-yl)methyl)-1H-1,2,3-triazol-4-yl)-1,1,1-trifluorobutan-2-yl 4-nitrobenzoate

Base Information

Chemical Name:(S)-2-(1-((4-chloro-2-cyanoquinolin-7-yl)methyl)-1H-1,2,3-triazol-4-yl)-1,1,1-trifluorobutan-2-yl 4-nitrobenzoate
CAS No.:1044278-46-7
Molecular Formula:C₂₄H₁₆ClF₃N₆O₄
Molecular Weight:544.877
Hs Code.:

Synonyms:(S)-2-(1-((4-chloro-2-cyanoquinolin-7-yl)methyl)-1H-1,2,3-triazol-4-yl)-1,1,1-trifluorobutan-2-yl 4-nitrobenzoate

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Chemical Property of (S)-2-(1-((4-chloro-2-cyanoquinolin-7-yl)methyl)-1H-1,2,3-triazol-4-yl)-1,1,1-trifluorobutan-2-yl 4-nitrobenzoate

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Technology Process of (S)-2-(1-((4-chloro-2-cyanoquinolin-7-yl)methyl)-1H-1,2,3-triazol-4-yl)-1,1,1-trifluorobutan-2-yl 4-nitrobenzoate

There total 7 articles about (S)-2-(1-((4-chloro-2-cyanoquinolin-7-yl)methyl)-1H-1,2,3-triazol-4-yl)-1,1,1-trifluorobutan-2-yl 4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1044278-45-6
7-(azidomethyl)-4-chloroquinoline-2-carbonitrile

: 1044277-04-4
(S)-1-ethyl-1-(trifluoromethyl)prop-2-yn-1-yl 4-nitrobenzoate

: 1044278-46-7
(S)-2-(1-((4-chloro-2-cyanoquinolin-7-yl)methyl)-1H-1,2,3-triazol-4-yl)-1,1,1-trifluorobutan-2-yl 4-nitrobenzoate

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 1044278-42-3
4-chloro-7-methylquinoline-2-carbonitrile

: 1044278-46-7
(S)-2-(1-((4-chloro-2-cyanoquinolin-7-yl)methyl)-1H-1,2,3-triazol-4-yl)-1,1,1-trifluorobutan-2-yl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 16 h / 20 °C

2: sodium azide / ethanol / 1 h / Reflux

3: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With N-Bromosuccinimide; copper(l) iodide; sodium azide; N-ethyl-N,N-diisopropylamine; dibenzoyl peroxide; In tetrahydrofuran; ethanol; acetonitrile;

Reference yield:

: 612-60-2
7-methylquinoline

: 1044278-46-7
(S)-2-(1-((4-chloro-2-cyanoquinolin-7-yl)methyl)-1H-1,2,3-triazol-4-yl)-1,1,1-trifluorobutan-2-yl 4-nitrobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 34 °C

2: N,N-Dimethylcarbamoyl chloride / dichloromethane / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 20 - 40 °C

4: trichlorophosphate / chloroform / 70 °C

5: N-Bromosuccinimide; dibenzoyl peroxide / acetonitrile / 16 h / 20 °C

6: sodium azide / ethanol / 1 h / Reflux

7: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 20 °C

With N-Bromosuccinimide; copper(l) iodide; sodium azide; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; N,N-Dimethylcarbamoyl chloride; trichlorophosphate; dibenzoyl peroxide; In tetrahydrofuran; ethanol; dichloromethane; chloroform; acetonitrile;