6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid

Base Information

Chemical Name:6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid
CAS No.:1268245-23-3
Molecular Formula:C₃₁H₂₄Cl₃N₃O₄
Molecular Weight:608.908
Hs Code.:

Synonyms:6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid

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Chemical Property of 6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid

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Technology Process of 6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid

There total 8 articles about 6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: C₃₂H₂₆Cl₃N₃O₄

: 1268245-23-3
6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid

Guidance literature:: C₃₂H₂₆Cl₃N₃O₄; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 24h;

With hydrogenchloride; In water; pH=5;

Reference yield:

: 6326-79-0
6-bromoisatin

: 1268245-23-3
6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide; sodium nitrite; sulfuric acid / water / 0.17 h / 0 °C

1.2: 0 - 20 °C

2.1: sulfuric acid / 0 °C / Reflux

2.2: pH 7

3.1: potassium carbonate / acetonitrile / 15 h / 20 °C

4.1: triethylamine / tris-(o-tolyl)phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 100 °C

5.1: palladium diacetate / diethyl ether / -50 - 20 °C / Inert atmosphere

6.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 24 h / 20 °C

6.2: pH 5

With lithium hydroxide monohydrate; sulfuric acid; water; potassium carbonate; triethylamine; sodium hydroxide; sodium nitrite; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; diethyl ether; water; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 660823-36-9
6-bromo-1H-indazole-3-carboxylic acid

: 1268245-23-3
6-(2-(2-chloro-4-((5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)phenyl)cyclopropyl)-1-methyl-1H-indazole-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 0 °C / Reflux

1.2: pH 7

2.1: potassium carbonate / acetonitrile / 15 h / 20 °C

3.1: triethylamine / tris-(o-tolyl)phosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / N,N-dimethyl-formamide / 16 h / 100 °C

4.1: palladium diacetate / diethyl ether / -50 - 20 °C / Inert atmosphere

5.1: water; lithium hydroxide monohydrate / tetrahydrofuran / 24 h / 20 °C

5.2: pH 5

With lithium hydroxide monohydrate; sulfuric acid; water; potassium carbonate; triethylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; acetonitrile;