(1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Base Information

Chemical Name:(1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane
CAS No.:128684-91-3
Molecular Formula:C₁₇H₃₆O₃Si
Molecular Weight:316.557
Hs Code.:

Synonyms:(1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Suppliers and Price of (1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Chemical Property:

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Technology Process of (1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

There total 18 articles about (1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 128684-90-2
Methyl (1R,3R,4R)-3-methoxy-4-<(triisopropylsilyl)oxy>cyclohexanecarboxylate

: 128684-91-3
(1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Yield given;
DOI:10.1021/ja00170a024

Reference yield:

: 118207-39-9
(4R,5S)-5-ethenyl-4-methoxytetrahydro-2H-pyran-2-one

: 128684-91-3
(1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 1.) -78 deg C, 90 min, 2.) 0 deg C, 60 min

2: toluene / 76 h / Heating

3: 1 N HCl / toluene; tetrahydrofuran / 3 h / Ambient temperature

4: diethyl ether; ethyl acetate

5: 1.) a) BH₃, 2.) 30percent H₂O₂, 3 N NaOH / 1.) a) THF, -78 deg C, 30 min, b) 0 deg C, 90 min, 2.) THF, RT, 3 h

6: 100 percent / Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

7: LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; borane; dihydrogen peroxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene;
DOI:10.1021/ja00170a024

Reference yield:

: 128684-67-3
ethyl (4R,5S)-5-hydroxy-4-methoxyhept-6-enoate

: 128684-91-3
(1R,2R,4R)-4-(hydroxymethyl)-2-methoxy-1-<(triisopropylsilyl)oxy>cyclohexane

Guidance literature:: Multi-step reaction with 8 steps

1: 77 percent / p-TsOH*H₂O, 4A molecular sieves / benzene / Ambient temperature

2: Et₃N / CH₂Cl₂ / 1.) -78 deg C, 90 min, 2.) 0 deg C, 60 min

3: toluene / 76 h / Heating

4: 1 N HCl / toluene; tetrahydrofuran / 3 h / Ambient temperature

5: diethyl ether; ethyl acetate

6: 1.) a) BH₃, 2.) 30percent H₂O₂, 3 N NaOH / 1.) a) THF, -78 deg C, 30 min, b) 0 deg C, 90 min, 2.) THF, RT, 3 h

7: 100 percent / Et₃N / CH₂Cl₂ / 1 h / 0 - 20 °C

8: LiAlH₄ / tetrahydrofuran / 0.5 h / 0 °C

With hydrogenchloride; sodium hydroxide; lithium aluminium tetrahydride; 4 A molecular sieve; borane; dihydrogen peroxide; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; toluene; benzene;
DOI:10.1021/ja00170a024